Inflammation and lipid signaling are intertwined modulators of homeostasis and immunity. In
addition to the extensively studied eicosanoids and inositol phospholipids, emerging studies …

Survival of multicellular organisms depends on their ability to fight infection, metabolize
nutrients, and store energy for times of need. Unsurprisingly, therefore, immunoregulatory …

Chronic, low-grade adipose tissue inflammation is a key etiological mechanism linking the
increasing incidence of type 2 diabetes (T2D) and obesity. It is well recognized that the …

Obesity and its comorbidities, including type 2 diabetes mellitus and cardiovascular disease,
are associated with a state of chronic low-grade inflammation that can be detected both …

Lipids and inflammation regulate each other. Early studies on this topic focused on the
systemic effects that the acute inflammatory response—and interleukins—had on lipid …

Obesity is featured by chronic systemic low-grade inflammation that eventually contributes to
the development of insulin resistance. Toll-like receptor 4 (TLR4) is an important mediator …

Lipid metabolism plays an essential role in modulating inflammation within the context of
acute and chronic diseases. Dietary and endogenous lipids possess pro-and …

Obesity leads to chronic, systemic inflammation and can lead to insulin resistance (IR), β-cell
dysfunction, and ultimately type 2 diabetes (T2D). This chronic inflammatory state …

There are currently over 1.9 billion people who are obese or overweight, leading to a rise in
related health complications, including insulin resistance, type 2 diabetes, cardiovascular …

As humans evolved, perhaps the two strongest selection determinants of survival were a
robust immune response able to clear bacterial, viral, and parasitic infection and an ability to …