Pregnancy loss is often caused by chromosomal abnormalities of the conceptus. The
prevalence of these abnormalities and the allocation of (ab) normal cells in embryonic and …

Chromosome instability is a hallmark of tumorigenesis. This study establishes that
chromosome instability is also common during early human embryogenesis. A new array …

Although chromosomal instability (CIN) is a common phenomenon in cleavage-stage
embryogenesis following in vitro fertilization (IVF),–, its rate in naturally conceived human …

Miscarriage is a common, complex trait affecting~ 15% of clinically confirmed pregnancies.
Here we present the results of large-scale genetic association analyses with 69,054 cases …

Pregnancy loss and perinatal death are devastating events for families. We assessed
'genomic autopsy'as an adjunct to standard autopsy for 200 families who had experienced …

Placentas can exhibit chromosomal aberrations that are absent from the fetus. The basis of
this genetic segregation, which is known as confined placental mosaicism, remains …

Chromosome instability is inherent to human IVF embryos, but the full spectrum and
developmental fate of chromosome anomalies remain uncharacterized. Using haplotyping …

Somatic cells acquire mutations throughout the course of an individual's life. Mutations
occurring early in embryogenesis are often present in a substantial proportion of, but not all …

Large-scale phenotyping efforts have demonstrated that approximately 25–30% of mouse
gene knockouts cause intrauterine lethality. Analysis of these mutants has largely focused …

Whole-chromosome imbalances affect over half of early human embryos and are the
leading cause of pregnancy loss. While these errors frequently arise in oocyte meiosis …