Modulation of MAPK signalling by immobilized adhesive peptides: Effect on stem cell response to BMP-9-derived peptides

S Beauvais, O Drevelle, MA Lauzon, A Daviau… - Acta biomaterialia, 2016 - Elsevier
Biomimetic materials were developed to regulate stem cell behaviour. We have analyzed
the influence of polycaprolactone (PCL) films, functionalized with adhesive peptides derived …

Effect of BMP-2 and/or BMP-9 on preosteoblasts attached to polycaprolactone functionalized by adhesive peptides derived from bone sialoprotein

O Drevelle, A Daviau, MA Lauzon, N Faucheux - Biomaterials, 2013 - Elsevier
Biomaterials functionalized by adhesive peptides improve the cell–substratum interaction.
However, their influence on the response of cells to growth factors is still poorly understood …

Combination of synthetic peptides derived from bone morphogenetic proteins and biomaterials for medical applications

H Senta, E Bergeron, O Drevelle, H Park… - … Canadian Journal of …, 2011 - Wiley Online Library
A critical‐size bone defect cannot repair itself. These defects are presently filled by bone
grafts or with biomaterials that mimic bone properties. The activity of bone cells is modulated …

Surface immobilization of bone morphogenetic protein 2 via a self-assembled monolayer formation induces cell differentiation

TLM Pohl, JH Boergermann, GK Schwaerzer, P Knaus… - Acta biomaterialia, 2012 - Elsevier
Bone extracellular matrix consists of a network of proteins in which growth factors, like bone
morphogenetic protein 2 (BMP-2), are embedded and released upon matrix turnover and …

Presentation of BMP-2 mimicking peptides in 3D hydrogels directs cell fate commitment in osteoblasts and mesenchymal stem cells

CM Madl, M Mehta, GN Duda, SC Heilshorn… - …, 2014 - ACS Publications
Many strategies for controlling the fate of transplanted stem cells rely on the concurrent
delivery of soluble growth factors that have the potential to produce undesirable secondary …

Synthetic peptide‐coated bone mineral for enhanced osteoblastic activation in vitro and in vivo

JY Lee, JE Choo, HJ Park, JB Park… - … Research Part A: An …, 2008 - Wiley Online Library
A 15‐mer synthetic peptide, designated P1, was derived from the bone morphogenetic
protein (BMP) receptor I and BMP receptor II binding domains of BMP‐2 for the purpose of …

Site-directed immobilization of an engineered bone morphogenetic protein 2 (BMP2) variant to collagen-based microspheres induces bone formation in vivo

C Siverino, S Fahmy-Garcia, D Mumcuoglu… - International Journal of …, 2022 - mdpi.com
For the treatment of large bone defects, the commonly used technique of autologous bone
grafting presents several drawbacks and limitations. With the discovery of the bone-inducing …

Differentiation of pre-osteoblast cells on poly (ethylene terephthalate) grafted with RGD and/or BMPs mimetic peptides

OF Zouani, C Chollet, B Guillotin, MC Durrieu - Biomaterials, 2010 - Elsevier
The bone morphogenetic proteins (BMPs) are cytokines of the transforming growth factor
beta family. Some BMPs such as BMP-2, BMP-7 and BMP-9 play a major role in the bone …

Modular peptides promote human mesenchymal stem cell differentiation on biomaterial surfaces

JS Lee, JS Lee, WL Murphy - Acta biomaterialia, 2010 - Elsevier
Molecular design strategies in biomedical applications often involve creating modular
“fusion” proteins, in which distinct domains within a single molecule can perform multiple …

Adhesion, intracellular signalling and osteogenic differentiation of mesenchymal progenitor cells and preosteoblasts on poly (epsilon) caprolactone films …

J Jann, O Drevelle, MA Lauzon, N Faucheux - Materials Science and …, 2020 - Elsevier
Biomaterials that can control the behaviour of stem cells play a major role in regenerative
medicine and tissue engineering. We previously showed that poly (epsilon) caprolactone …