Background Elevated levels of total cholesterol and low‐density lipoprotein play an
important role in the development of atheromas and, therefore, in cardiovascular diseases …

Statins are one of the most commonly prescribed medications, and it is surprising that the
timing of statin administration is controversial—society guidelines are also silent on this …

The current limited evidence suggests that short-acting statins should be given in the
evening whereas long-acting statins could be given at any time of the day with allowing …

Background Evidence about the optimal time of day at which to administer statins is lacking.
Objective The objective of this study is to synthesize evidence about effects of morning vs …

Objective: To determine the best time to administer statins for optimal lowering of low-density
lipoprotein cholesterol (LDL-C) by reviewing the clinical evidence evaluating the …

Purpose We conducted a meta-analysis of randomized controlled trials (RCTs) and quasi-
RCTs to synthesize evidence about the efficacy and safety of alternate-day vs daily dosing of …

Statins are widely prescribed for the primary and secondary prevention of coronary artery
disease. They act by inhibiting the enzyme HMG CoA reductase, which controls synthesis of …

The potential of chronopharmacology for treatment of atheros... : Current Opinion in Lipidology
The potential of chronopharmacology for treatment of atherosclerosis : Current Opinion in …

BACKGROUND: Statins are the treatment of choice for lowering LDL-C levels and reducing
cardiovascular events. They have a remarkable safety profile, although some patients do not …

Since 2014, guidelines for the management of lipid disorders to reduce cardiovascular (CV)
events have been updated in the United States, the United Kingdom, Europe, and Canada …