Methods derived from CUT&RUN and CUT&Tag enable genome-wide mapping of the
localization of proteins on chromatin from as few as one cell. These and other mapping …

Chromatin immunoprecipitation followed by sequencing (ChIP-seq) has been instrumental
to our current view of chromatin structure and function. It allows genome-wide mapping of …

Chromatin profiling at locus resolution uncovers gene regulatory features that define cell
types and developmental trajectories, but it remains challenging to map and compare …

Technologies that profile chromatin modifications at single-cell resolution offer enormous
promise for functional genomic characterization, but the sparsity of the measurements and …

Understanding chromatin regulation holds enormous promise for controlling gene
regulation, predicting cellular identity, and developing diagnostics and cellular therapies …

Chromatin profiling in single cells has been extremely challenging and almost exclusively
limited to histone proteins. In cases where single-cell methods have shown promise, many …

Abstract We recently introduced Cleavage Under Targets & Tagmentation (CUT&Tag), an
epigenomic profiling strategy in which antibodies are bound to chromatin proteins in situ in …

Chromatin modifications orchestrate the dynamic regulation of gene expression during
development and in disease. Bulk approaches have characterized the wide repertoire of …

Hundreds of chromatin regulators (CRs) control chromatin structure and function by
catalyzing and binding histone modifications, yet the rules governing these key processes …

Abstract We previously reported Paired-Tag, a combinatorial indexing-based method that
can simultaneously map histone modifications and gene expression at single-cell resolution …