SARS-CoV-2 ORF8 accessory protein is a virulence factor

M Bello-Perez, J Hurtado-Tamayo, AZ Mykytyn… - Mbio, 2023 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) encodes six accessory
proteins (3a, 6, 7a, 7b, 8, and 9b) for which limited information is available on their role in …

SARS-CoV-2 ORF8 modulates lung inflammation and clinical disease progression

ME McGrath, Y Xue, L Taylor, C Dillen… - PLoS …, 2024 - journals.plos.org
The virus severe acute respiratory syndrome coronavirus 2, SARS-CoV-2, is the causative
agent of the current COVID-19 pandemic. It possesses a large 30 kilobase (kb) genome that …

Understanding the role of SARS-CoV-2 ORF3a in viral pathogenesis and COVID-19

J Zhang, A Ejikemeuwa, V Gerzanich, M Nasr… - Frontiers in …, 2022 - frontiersin.org
The ongoing SARS-CoV-2 pandemic has shocked the world due to its persistence, COVID-
19-related morbidity and mortality, and the high mutability of the virus. One of the major …

SARS-CoV-2 ORF6 protein does not antagonize interferon signaling in respiratory epithelial Calu-3 cells during infection

M Li, K Ayyanathan, M Dittmar, J Miller, I Tapescu… - Mbio, 2023 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused millions of
deaths, posing a substantial threat to global public health. Viruses evolve different strategies …

SARS-CoV-2 ORF8 forms intracellular aggregates and inhibits IFNγ-induced antiviral gene expression in human lung epithelial cells

H Geng, S Subramanian, L Wu, HF Bu… - Frontiers in …, 2021 - frontiersin.org
Infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes
COVID-19, a disease that involves significant lung tissue damage. How SARS-CoV-2 …

SARS-CoV-2 ORF8 is a viral cytokine regulating immune responses

M Kohyama, T Suzuki, W Nakai, C Ono… - International …, 2023 - academic.oup.com
Many patients with severe COVID-19 suffer from pneumonia and the elucidation of the
mechanisms underlying the development of this severe condition is important. The in vivo …

SARS-CoV-2 ORF8: One protein, seemingly one structure, and many functions

S Vinjamuri, L Li, M Bouvier - Frontiers in immunology, 2022 - frontiersin.org
SARS-CoV-2 is the virus responsible for the COVID-19 pandemic. The genome of SARS-
CoV-2 encodes nine accessory proteins that are involved in host-pathogen interaction …

Lost in deletion: The enigmatic ORF8 protein of SARS-CoV-2

L Zinzula - Biochemical and biophysical research communications, 2021 - Elsevier
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome contains nine
open reading frames (ORFs) that encode for accessory proteins which, although …

SARS-CoV-2 accessory protein ORF8 is secreted extracellularly as a glycoprotein homodimer

K Matsuoka, N Imahashi, M Ohno, H Ode… - Journal of Biological …, 2022 - ASBMB
ORF8 is an accessory protein encoded by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2). Consensus regarding the biological functions of ORF8 is lacking, largely …

SARS-CoV-2 accessory proteins in viral pathogenesis: knowns and unknowns

N Redondo, S Zaldívar-López, JJ Garrido… - Frontiers in …, 2021 - frontiersin.org
There are still many unanswered questions concerning viral SARS-CoV-2 pathogenesis in
COVID-19. Accessory proteins in SARS-CoV-2 consist of eleven viral proteins whose roles …