Tumor-pH-sensitive PLLA-based microsphere with acid cleavable acetal bonds on the backbone for efficient localized chemotherapy

J Li, X Zhang, M Zhao, L Wu, K Luo, Y Pu… - …, 2018 - ACS Publications
Nanoparticle-and microsphere-based drug delivery systems (DDSs) have attracted wide
attention in cancer therapy; those DDSs that are responsive to tumor environment can …

Tumor-targeted aggregation of pH-sensitive nanocarriers for enhanced retention and rapid intracellular drug release

W Wu, Q Zhang, J Wang, M Chen, S Li, Z Lin, J Li - Polymer Chemistry, 2014 - pubs.rsc.org
Development of nanocarriers, which can selectively accumulate and remain within the tumor
tissue matrix, is beneficial for non-invasive cancer diagnosis and therapy. In this study, a …

Hydrophobicity‐Adaptive Polymers Trigger Fission of Tumor‐Cell‐Derived Microparticles for Enhanced Anticancer Drug Delivery

H Liu, S Xu, T Yong, Z Wei, N Bie, X Zhang… - Advanced …, 2023 - Wiley Online Library
Tumor‐cell‐derived microparticles (MPs) can function as anticancer drug‐delivery carriers.
However, short blood circulation time, large‐size‐induced insufficient tumor accumulation …

Biocompatible and biodegradable polymersomes for pH-triggered drug release

GY Liu, LP Lv, CJ Chen, XS Liu, XF Hu, J Ji - Soft Matter, 2011 - pubs.rsc.org
Nano-sized biocompatible and biodegradable polymersomes were prepared based on poly
(D, L-lactide)-block-poly (2-methacryloyloxyethyl phosphorylcholine)(PLA-b-PMPC) diblock …

Synergetic enhancement of antitumor efficacy with charge-reversal and reduction-sensitive polymer micelles

SX Li, L Liu, LJ Zhang, B Wu, CX Wang, W Zhou… - Polymer …, 2016 - pubs.rsc.org
The important characteristics of a nanoparticle-based anticancer drug delivery system at
least include high stability in blood, highly efficient tumor cellular uptake and stimuli …

Polylactide-graft-doxorubicin Nanoparticles with Precisely Controlled Drug Loading for pH-Triggered Drug Delivery

Y Yu, CK Chen, WC Law, E Weinheimer… - …, 2014 - ACS Publications
Nanoparticles (NPs) with high drug loading and pH-responsivity were prepared by
nanoprecipitation of a hydrophobic polymer-drug conjugate (PDC). The PDC, polylactide …

Biodegradable poly (ε-caprolactone)-g-poly (2-hydroxyethyl methacrylate) graft copolymer micelles as superior nano-carriers for “smart” doxorubicin release

R Cheng, X Wang, W Chen, F Meng, C Deng… - Journal of Materials …, 2012 - pubs.rsc.org
Biodegradable micelles were prepared from poly (ε-caprolactone)-g-poly (2-hydroxyethyl
methacrylate)(PCL-g-PHEMA) graft copolymers and investigated for controlled release of …

Development of paclitaxel-loaded poly (lactic acid)/hydroxyapatite core–shell nanoparticles as a stimuli-responsive drug delivery system

S Lee, T Miyajima… - Royal Society …, 2021 - royalsocietypublishing.org
Biodegradable nanoparticles have been well studied as biocompatible delivery systems.
Nanoparticles of less than 200 nm in size can facilitate the passive targeting of drugs to …

Effects of pH-sensitive chain length on release of doxorubicin from mPEG-b-PH-b-PLLA nanoparticles

R Liu, B He, D Li, Y Lai, J Chang… - International Journal of …, 2012 - Taylor & Francis
Background Two methoxyl poly (ethylene glycol)-poly (L-histidine)-poly (L-lactide)(mPEG-
PH-PLLA) triblock copolymers with different poly (L-histidine) chain lengths were …

Tumor-microenvironment double-responsive shrinkable nanoparticles fabricated via facile assembly of laponite with a bioactive oligosaccharide for anticancer therapy

G Zhong, L Wang, H Jin, X Li, D Zhou, G Wang… - Journal of Drug Delivery …, 2023 - Elsevier
The application of nanoparticle-based delivery systems is limited by uncontrolled drug
release, limited tumor penetration, and poor stability. To solve these problems, a tumor …