Gene expression in human tissue has primarily been studied on the transcriptional level,
largely neglecting translational regulation. Here, we analyze the translatomes of 80 human …

The extent of translational control of gene expression in mammalian tissues remains largely
unknown. Here we perform genome-wide RNA sequencing and ribosome profiling in heart …

Aims Cardiovascular disease, one of the most common causes of death in western
populations, is characterized by changes in RNA splicing and expression. Circular RNAs …

Alternative splicing generates differing RNA isoforms that govern phenotypic complexity of
eukaryotes. Its malfunction underlies many diseases, including cancer and cardiovascular …

Rationale: Accurate and comprehensive de novo transcriptome profiling in heart is a central
issue to better understand cardiac physiology and diseases. Although significant progress …

Heart function requires sophisticated regulatory networks to orchestrate organ development,
physiological responses, and environmental adaptation. Until recently, it was thought that …

Rationale: RNA-binding motif protein 20 (RBM20) is essential for normal splicing of many
cardiac genes, and loss of RBM20 causes dilated cardiomyopathy. Given its role in splicing …

Deep sequencing techniques and advanced data analysis methods recently enabled the
characterization of thousands of circular RNA isoforms (circRNAs) from a number of tissues …

Aim Heart disease is recognized as a consequence of dysregulation of cardiac gene
regulatory networks. Previously, unappreciated components of such networks are the long …

Advances in developmental cardiology have increased our understanding of the early
aspects of heart differentiation. However, understanding noncoding RNA (ncRNA) …