Antidepressants are the most common treatment for moderate or severe depression. Side
effects are crucial indicators for antidepressants, but their expression varies widely among …

Background Major depression is one of the most disabling health conditions internationally.
In recent years, new generation antidepressant medicines have become very widely …

Background It has been suggested that outcomes of antidepressant treatment for major
depressive disorder could be significantly improved if treatment choice is informed by …

Importance Antidepressants are a first line treatment for depression. However, only a third of
individuals remit after the first treatment. Genetic variation likely regulates antidepressant …

Antidepressants exhibit a large variation in efficacy in treated individuals, and increasing
evidence suggests that individual genetics contribute to antidepressant treatment response …

Individuals with depression differ substantially in their response to treatment with
antidepressants. Specific predictors explain only a small proportion of these differences. To …

Genetic polymorphism contributes to variation in response to drug treatment of depression.
We conducted three independent 6-week treatment studies in outpatients with major …

Antidepressants demonstrate modest response rates in the treatment of major depressive
disorder (MDD). Despite previous genome-wide association studies (GWAS) of …

There are currently no reliable approaches for correctly identifying which patients with major
depressive disorder (MDD) will respond well to antidepressant therapy. However, recent …

The “antidepressant efficacy” survey (AES) was deployed to> 50,000 23andMe, Inc.
research participants to investigate the genetic basis of treatment-resistant depression …