Introduction. Lupus nephritis (LN) is an autoimmune glomerulonephritis secondary to
systemic lupus erythematosus. Commonly, immunosuppressive agents are required for …

(5R)-5-hydroxytriptolide (LLDT-8), a triptolide derivative with low toxicity, was previously
reported to have strong immunosuppressive effects both in vitro and in vivo, but it remains …

The pathogenesis of lupus nephritis is mainly attributable to a complex interaction between
the innate and adaptive immune systems, including T and B cell function abnormalities. In …

Objective Current treatment options for lupus are far from optimal. Previously, we reported
that phosphatidylinositol 3‐kinase/Akt/mammalian target of rapamycin, MEK‐1/ERK‐1, 2 …

Treg cells are essential for re-establishing self-tolerance in lupus. However, given that direct
Treg therapies may be inadequate to control autoimmunity and inflammation, a strategy of …

Lupus nephritis (LN) is a challenging problem that affects 50% of patients with systemic
lupus erythematosus (SLE) without effective therapy. Here, we report that A77 1726, the …

Adoptive transfer of regulatory T cells (Tregs) can delay disease progression and reduce
mortality in lupus-prone mice. Here, we tested whether complex (IL-2C) consisting of IL-2 …

An increasing body of data has shown that erythropoietin (EPO) plays multiple roles in
inflammation control and immunoregulation. However, less attention has been given to its …

Recent data have shown that piperlongumine (PL), an important component of Piper longum
fruits, is known to possess anti-inflammatory and vascular-protective activities. This study …

Treatment of systemic lupus erythematosus (SLE), a chronic inflammatory disease, involves
the long-term use of immunosuppressive agents with significant side effects. New …