Epilepsy is a complex, multifactorial disease characterized by spontaneous recurrent
seizures and an increased incidence of comorbid conditions such as anxiety, depression …

The term 'glutamate–glutamine cycle'was coined several decades ago based on the
observation that using certain 14 C-labeled precursors for studies of brain metabolism the …

Glutamate is an essential excitatory neurotransmitter in the central nervous system, playing
an indispensable role in neuronal development and memory formation. The dysregulation of …

Epilepsy is broadly characterized by aberrant neuronal excitability. Glutamate is the
predominant excitatory neurotransmitter in the adult mammalian brain; thus, much of past …

Epilepsy is a broad range of neurological conditions that are manifested as seizures. Two
major hypotheses—glutamate and potassium—have been proposed for the mechanism of …

Astrocytes play a critical role in regulation of extracellular neurotransmitter levels in the
central nervous system. This function is particularly prominent for the excitatory amino acid …

The generation of prolonged neuronal activity depends on the maintenance of synaptic
neurotransmitter pools. The astrocytic glutamate-glutamine cycle is a major mechanism for …

Epileptic syndromes have very diverse primary causes, which may be genetic,
developmental or acquired. In rodent models, altering glutamate receptor or glutamate …

Although glutamate is usually thought of as the major excitatory neurotransmitter in brain, it
is important to note that glutamate has many other fates in brain, including oxidation for …

The synthesis, release, reuptake, and metabolism of the excitatory and inhibitory
neurotransmitters glutamate and GABA, respectively, are tightly controlled. Given the role …