Extracellular environment-controlled angiogenesis, and potential application for peripheral nerve regeneration

S Saio, K Konishi, H Hohjoh, Y Tamura… - International Journal of …, 2021 - mdpi.com
Endothelial cells acquire different phenotypes to establish functional vascular networks.
Vascular endothelial growth factor (VEGF) signaling induces endothelial proliferation …

The interaction of stem cells and vascularity in peripheral nerve regeneration

S Saffari, TM Saffari, DJO Ulrich… - Neural Regeneration …, 2021 - journals.lww.com
The degree of nerve regeneration after peripheral nerve injury can be altered by the
microenvironment at the site of injury. Stem cells and vascularity are postulated to be a part …

Blood vessel remodeling in late stage of vascular network reconstruction is essential for peripheral nerve regeneration

G Wang, P Lu, P Qiao, P Zhang, X Cai… - Bioengineering & …, 2022 - Wiley Online Library
One of the bottlenecks of advanced study on tissue engineering in regenerative medicine is
rapid and functional vascularization. For a deeper comprehension of vascularization, the …

Novel roles of perivascular nerves on neovascularization

L Hao, Z Zou, H Tian, Y Zhang, C Song, H Zhou… - Neurological …, 2015 - Springer
Neovascularization, including angiogenesis, arteriogenesis and vasculogenesis, occurs in
physiological and pathological state. Efficient and controlled reconstruction of functional …

Vascularization via activation of VEGF-VEGFR signaling is essential for peripheral nerve regeneration

Y Nishida, Y Yamada, H Kanemaru… - Biomedical …, 2018 - jstage.jst.go.jp
Peripheral nerve injury has been suggested to up-regulate mRNA for the vascular
endothelial growth factor (VEGF) which enhances nerve regeneration. VEGF is known to …

Parallels between the developing vascular and neural systems: Signaling pathways and future perspectives for regenerative medicine

I Elorza Ridaura, S Sorrentino, L Moroni - Advanced Science, 2021 - Wiley Online Library
Neurovascular disorders, which involve the vascular and nervous systems, are common.
Research on such disorders usually focuses on either vascular or nervous components …

From the vascular microenvironment to neurogenesis

XT Yang, YY Bi, DF Feng - Brain research bulletin, 2011 - Elsevier
In response to injury, the function of the adult mammalian central nervous system (CNS) is
repaired by angiogenesis and neurogenesis. The proliferation, differentiation and migration …

[HTML][HTML] Endothelial cells promote the proliferation and migration of Schwann cells

DH Meng, JP Zou, QT Xu, JY Wang, JQ Yu… - Annals of …, 2022 - ncbi.nlm.nih.gov
Background After peripheral nerve injury, Schwann cells proliferate and migrate to the
injured site, thereby promoting peripheral nerve regeneration. The process is regulated by …

Research progress on the mechanism of angiogenesis in wound repair and regeneration

Z Shi, C Yao, Y Shui, S Li, H Yan - Frontiers in Physiology, 2023 - frontiersin.org
Poor wound healing and pathological healing have been pressing issues in recent years, as
they impact human quality of life and pose risks of long-term complications. The study of …

Human endothelial cells secrete neurotropic factors to direct axonal growth of peripheral nerves

JM Grasman, DL Kaplan - Scientific reports, 2017 - nature.com
Understanding how nerves spontaneously innervate tissues or regenerate small injuries is
critical to enhance material-based interventions to regenerate large scale, traumatic injuries …