Potassium channels belong to the largest and the most diverse super-families of ion
channels. Among them, Ca 2+-activated K+ channels (KCa) comprise many members …

Cancer is a major cause of death. The diversity of cancer types and the propensity of
cancers to acquire resistance to therapies, including new molecularly targeted and immune …

Background: The KCa3. 1 channel is the intermediate-conductance member of the Ca2+-
activated K channel superfamily. It is widely expressed in excitable and non-excitable cells …

Abstract Ca 2+-activated K+ channels (KCa) are classified into three subtypes: big
conductance (BKCa), intermediate conductance (IKCa), and small conductance (SKCa) KCa …

The ion Ca 2+ is a ubiquitous second messenger that mediates a variety of cellular
functions. Dysfunction of the mechanisms involved in Ca 2+ homeostasis underlies a …

Tight control of basal cytosolic Ca 2+ concentration is essential for cell survival and to fine-
tune Ca 2+-dependent cell functions. A way to control this basal cytosolic Ca 2+ …

The study of calcium channels in molecular mechanisms of cancer transformation is still a
novel area of research. Several studies, mostly conducted on cancer cell lines, however …

The Ca2+ ion is used ubiquitously as an intracellular signaling molecule due to its high
external and low internal concentration. Many Ca2+-sensing ion channel proteins have …

Large-conductance Ca2+-activated K+ (BK-Ca) channels differ from most of other K+
channels in that their activation is under dual control, ie, activated by either increase in …

Recent improvements in the patch-clamp technique have opened the way to detailed
studies of ionic channels controlled by intracellular key substances such as Ca 2÷. One …