Ca2+ as a Mediator of Ischemic Preconditioning

H Miyawaki, M Ashraf - Circulation research, 1997 - Am Heart Assoc
We tested the hypothesis that elevation of [Ca2+] i during ischemic preconditioning (IPC)
stimulates protein kinase C (PKC), which confers the protection against the ischemic injury …

Calcium preconditioning elicits strong protection against ischemic injury via protein kinase C signaling pathway

H Miyawaki, X Zhou, M Ashraf - Circulation research, 1996 - Am Heart Assoc
We tested the hypothesis that elevation of [Ca2+] i during Ca2+ preconditioning (CPC) is a
strong activator of protein kinase C (PKC) and confers unique protection against ischemic …

Ischemic preconditioning translocates PKC-δ and-ε, which mediate functional protection in isolated rat heart

S Kawamura, KI Yoshida, T Miura… - American Journal …, 1998 - journals.physiology.org
Protein kinase C (PKC) plays an important role in mediating ischemic preconditioning (PC).
However, the relationship between PKC isoforms and PC is still uncertain. We analyzed …

Post-conditioning protects rat cardiomyocytes via PKCε-mediated calcium-sensing receptors

W Zhang, F Lu, Y Zhao, L Wang, Y Tian, Z Pan… - Biochemical and …, 2007 - Elsevier
Protein kinase C (PKC) plays a role in cardioprotection through reduction of intracellular
Ca2+ concentration [Ca2+] i during ischemic preconditioning (IPC). Cardioprotection against …

Isoproterenol mimics calcium preconditioning-induced protection against ischemia

H Miyawaki, M Ashraf - American Journal of Physiology …, 1997 - journals.physiology.org
We tested the hypothesis that a transient increase in intracellular calcium concentration
([Ca2+] i) before prolonged ischemia triggers the activation of protein kinase C (PKC) …

Effect of ischemic preconditioning and PKC activation on acidification during ischemia in rat heart

W Chen, W Wetsel, C Steenbergen… - Journal of molecular and …, 1996 - Elsevier
Ischemic preconditioning (PC) has been shown to attenuate intracellular acidification during
a subsequent period of ischemia, to minimize stunning, and to decrease infarct size. PKC …

Role of Intracellular Ca2+ in Activation of Protein Kinase C During Ischemic Preconditioning

K Node, M Kitakaze, H Sato, T Minamino… - Circulation, 1997 - Am Heart Assoc
Background Activation of protein kinase C plays an important role in ischemic
preconditioning. Given that protein kinase C is activated by an increase in the intracellular …

Implication of protein kinase C-α, δ, and ε isoforms in ischemic preconditioning in perfused rat hearts

K Yoshida, S Kawamura, Y Mizukami… - The journal of …, 1997 - jstage.jst.go.jp
Ischemic preconditioning is a phenomenon in which one or several cycle (s) of brief
ischemia-reperfusion protects the myocardium against the cell injury caused by subse quent …

PKC-ε is upstream and PKC-α is downstream of mitoKATP channels in the signal transduction pathway of ischemic preconditioning of human myocardium

A Hassouna, BM Matata… - American Journal of …, 2004 - journals.physiology.org
Protein kinase C (PKC) is involved in the process of ischemic preconditioning (IPC),
although the precise mechanism is still a subject of debate. Using specific PKC inhibitors …

KATP channels are common mediators of ischemic and calcium preconditioning in rabbits

I Kouchi, T Murakami, R Nawada… - American Journal …, 1998 - journals.physiology.org
Calcium preconditioning (CPC), like ischemic preconditioning (IPC), reduces myocardial
infarct size in dogs and rats. ATP-sensitive potassium (KATP) channels induce …