1.1. Discovery of the Phospholipase A2 Superfamily Phospholipases represent one of the
earliest enzyme activities to be identified and studied, and the phospholipase A2 (PLA2) …

With the recent discoveries of novel forms of phospholipases A2 (PLA2S), 2 new schemes
for the roles of various PLA2S in lipid metabolism must be considered. The type II 14‐kDa …

Phospholipases A2 (PLA2) are widely distributed in nature and are well characterized
proteins with respect to their catalytic and pharmacological activities. A wealth of structural …

We showed in an earlier study (Arita, H., Hanasaki, K., Nakano, T., Oka, S., Teraoka, H., and
Matsumoto, K.(1991) J. Biol. Chem. 266, 19139-19141) that there is a high affinity and …

Introduction. Phospholipase A2 (PLA2) is a group of lipolytic enzymes that catalyze the
hydrolysis of fatty acid ester bonds at the sn-2 position of phospholipids. This enzyme is …

Endogenous proteins isolated from the serum of snakes have been found to be natural
inhibitors displaying anti-hemorrhagic, anti-neurotoxic or anti-myotoxic activity. Some of …

Publisher Summary A substantial amount of research has been applied to Phospholipase A
2 (PLA 2) enzymes, from a mechanistic understanding of enzyme structure function to the …

Phospholipase A2 (PLA2) participates in a wide range of cellular processes including
inflammation and transmembrane signaling. A human nonpancreatic secretory PLA2 (hnps …

Phospholipases A2 (PLA2s) constitute major components of snake venoms and have been
extensively investigated not only because they are very abundant in these venoms but …

Abstract Phospholipase A 2 (PLA 2) cleave phospholipids preferentially at the sn-2 position,
liberating free fatty acids and lysophospholipids. They are classified into six main groups …