Harnessing and delivering microbial metabolites as therapeutics via advanced pharmaceutical approaches

LM Williams, S Cao - Pharmacology & Therapeutics, 2024 - Elsevier
Microbial metabolites have emerged as key players in the interplay between diet, the gut
microbiome, and host health. Two major classes, short-chain fatty acids (SCFAs) and …

Not just a gut feeling: a deep exploration of functional bacterial metabolites that can modulate host health

A Gold, J Zhu - Gut microbes, 2022 - Taylor & Francis
Bacteria have been known to reside in the human gut for roughly two centuries, but their
modulatory effects on host health status are still not fully characterized. The gut microbiota is …

Human microbial metabolites as a source of new drugs

S Saha, DK Rajpal, JR Brown - Drug discovery today, 2016 - Elsevier
Highlights•Bacterial metabolism of high fiber foods has proven benefits for human
health.•Gut microbiota produce metabolites that interact with the human immune …

Modulation of microbially derived short-chain fatty acids on intestinal homeostasis, metabolism, and neuropsychiatric disorder

S Xiao, S Jiang, D Qian, J Duan - Applied Microbiology and Biotechnology, 2020 - Springer
A diverse range of symbiotic gut bacteria codevelops with the host and is considered a
metabolic “organ” that not only facilitates harvesting of nutrients from the dietary components …

The path toward using microbial metabolites as therapies

HC Descamps, B Herrmann, D Wiredu, CA Thaiss - EBioMedicine, 2019 - thelancet.com
Metabolites have emerged as the quintessential effectors mediating the impact of the
commensal microbiome on human physiology, both locally at the sites of microbial …

From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites

A Koh, F De Vadder, P Kovatcheva-Datchary… - Cell, 2016 - cell.com
A compelling set of links between the composition of the gut microbiota, the host diet, and
host physiology has emerged. Do these links reflect cause-and-effect relationships, and …

Introduction to the Thematic Minireview Series: Host-microbiome metabolic interplay

R Banerjee - Journal of Biological Chemistry, 2017 - ASBMB
Long before the recent thrust of scientific research on the microbiome, the importance of its
interface with the host was being acknowledged by practices such as probiotic …

Gut-microbiota derived bioactive metabolites and their functions in host physiology

N Debnath, R Kumar, A Kumar, PK Mehta… - Biotechnology and …, 2021 - Taylor & Francis
Every individual harbours a complex, diverse and mutualistic microbial flora in their intestine
and over the time it became an integral part of the body, affecting a plethora of activities of …

Microbial metabolites in health and disease: Navigating the unknown in search of function

KB Martinez, V Leone, EB Chang - Journal of Biological Chemistry, 2017 - ASBMB
The gut microbiota has been implicated in the development of a number of chronic
gastrointestinal and systemic diseases. These include inflammatory bowel diseases, irritable …

Quantifying Gut Microbial Short-Chain Fatty Acids and Their Isotopomers in Mechanistic Studies Using a Rapid, Readily Expandable LC–MS Platform

CYC Weng, C Suarez, SE Cheang, G Couture… - Analytical …, 2024 - ACS Publications
Short-chain fatty acids (SCFAs) comprise the largest group of gut microbial fermentation
products. While absorption of most nutrients occurs in the small intestine, indigestible dietary …