Macrophages are crucial in the progression of atherosclerotic cardiovascular disease
(ASCVD). In the atherosclerotic lesions, macrophages play a central role in maintaining …

After activation, cells of the myeloid lineage undergo robust metabolic transitions, as well as
discrete epigenetic changes, that can dictate both ongoing and future inflammatory …

Hypercholesterolemia contributes to the chronic inflammatory response during the
progression of atherosclerosis, in part by favoring cholesterol loading in macrophages and …

Atherosclerosis is characterized by chronic low grade inflammation of arteries that results in
the development of lipid dense plaques. Chronic inflammation induced by Western-type diet …

Over the last decade, there has been a growing interest to understand the link between
metabolism and the immune response in the context of metabolic diseases but also beyond …

Macrophage immunometabolism, the changes in intracellular metabolic pathways that alter
the function of these highly plastic cells, has been the subject of intense interest in the past …

A key aspect of atherosclerosis is the maladaptive inflammatory response to lipoprotein
accumulation in the artery. The failure to decrease lipid accumulation, to clear apoptotic …

Macrophages are the central immune cells in atherosclerosis (AS) and play a critical role in
the initiation, progression and invasion of atherosclerotic plaques. Metabolic reprogramming …

An emerging theory is that macrophages are heterogenous; an attribute that allows them to
change behavior and execute specific functions in disease processes. This review aims to …

Atherosclerotic cardiovascular disease (CVD) is a lipid-driven chronic inflammatory disease,
in which macrophages are responsible for taking up these lipids and driving disease …