The ATP binding-cassette superfamily corresponds the mostly transmembrane transporters
family found in humans. These proteins actively transport endogenous and exogenous …

Cancer is one of the leading causes of mortality in the developed countries. The search for
novel drug candidates is a priority goal for cancer therapy. However, the emergence of drug …

ATP Binding Cassette (ABC) transporters form a special family of membrane proteins,
characterized by homologous ATP-binding, and large, multispanning transmembrane …

The concept of multidrug resistance (MDR) in tumors originated from the pioneer work of
June Biedler in the early 1970s, who identified a wide profile of cross-resistance in Chinese …

The ATP‐binding cassette (ABC) transporter superfamily is one of the largest membrane
protein families existing in wide spectrum of organisms from prokaryotes to human. ABC …

The ABC (ATP-binding cassette) transporter is one of the largest and most ancient protein
families with members functioning from protozoa to human. The resistance of cancer and …

ATP-binding cassette (ABC) genes play a role in the resistance of malignant cells to
anticancer agents. The ABC gene products, including ABCB1 (P-glycoprotein), ABCC1 …

Background ABC transporters have attracted considerable attention for their function as drug
transporters in a broad range of tumours and are therefore considered as major players in …

Multidrug transporter proteins are best known for their contributions to chemoresistance
through the efflux of anticancer drugs from cancer cells. However, a considerable body of …

ATP-binding cassette (ABC) transporters mediate multidrug resistance in cancer. In contrast
to DNA single nucleotide polymorphisms in normal tissues, the role of mutations in tumors is …