Sargramostim (rhu GM-CSF) as cancer therapy (systematic review) and an immunomodulator. A drug before its time?
HM Lazarus, CE Ragsdale, RP Gale… - Frontiers in …, 2021 - frontiersin.org
Background Sargramostim [recombinant human granulocyte-macrophage colony-
stimulating factor (rhu GM-CSF)] was approved by US FDA in 1991 to accelerate bone …
stimulating factor (rhu GM-CSF)] was approved by US FDA in 1991 to accelerate bone …
The role of sargramostim (rhGM-CSF) as immunotherapy
EK Waller - The oncologist, 2007 - academic.oup.com
GM-CSF stimulates the differentiation of hematopoietic progenitors to monocytes and
neutrophils, and reduces the risk for febrile neutropenia in cancer patients. GM-CSF also …
neutrophils, and reduces the risk for febrile neutropenia in cancer patients. GM-CSF also …
Randomized trial comparing the tolerability of sargramostim (yeast-derived RhuGM-CSF) and filgrastim (bacteria-derived RhuG-CSF) in cancer patients receiving …
RA Beveridge, JA Miller, AN Kales, RA Binder… - Supportive care in …, 1997 - Springer
A prospective, randomized, double-blind, multicenter study in cancer patients receiving
myelosuppressive chemotherapy was undertaken to evaluate and compare the tolerability of …
myelosuppressive chemotherapy was undertaken to evaluate and compare the tolerability of …
Recombinant human granulocyte-macrophage colony-stimulating factor (rhu GM-CSF) as adjuvant therapy for invasive fungal diseases
TK Chen, JS Batra, DE Michalik… - Open Forum …, 2022 - academic.oup.com
Background Sargramostim (yeast-derived, glycosylated recombinant human granulocyte-
macrophage colony-stimulating factor [rhu GM-CSF]) augments innate and adaptive immune …
macrophage colony-stimulating factor [rhu GM-CSF]) augments innate and adaptive immune …
A comparison of efficacy of sargramostim (yeast-derived RhuGM-CSF) and filgrastim (bacteria-derived RhuG-CSF) in the therapeutic setting of chemotherapy-induced …
RA Beveridge, JA Miller, AN Kales, RA Binder… - Cancer …, 1998 - Taylor & Francis
A randomized, double-blind, multicenter study in 181 afebrile cancer patients with ANC
levels< 500/μL receiving myelosuppressive chemotherapy was undertaken to compare …
levels< 500/μL receiving myelosuppressive chemotherapy was undertaken to compare …
Sargramostim (rhu GM-CSF) improves survival of non-human primates with severe bone marrow suppression after acute, high-dose, whole-body irradiation
NP Clayton, RC Khan-Malek, CA Dangler… - Radiation …, 2021 - meridian.allenpress.com
Exposure to acute, high-dose, whole-body ionizing radiation results in bone marrow failure
(hematopoietic acute radiation syndrome with resultant infection, bleeding, anemia, and …
(hematopoietic acute radiation syndrome with resultant infection, bleeding, anemia, and …
Current state and future opportunities in granulocyte colony-stimulating factor (G-CSF)
H Link - Supportive Care in Cancer, 2022 - Springer
Granulocyte colony-stimulating factor (G-CSF), a protein that stimulates the growth of new
blood cells, was isolated from human cells by Malcolm Moore and Karl Welte in 1984 [1]. It …
blood cells, was isolated from human cells by Malcolm Moore and Karl Welte in 1984 [1]. It …
A dose-escalation study of aerosolized sargramostim in the treatment of metastatic melanoma: an NCCTG Study
SN Markovic, VJ Suman, WK Nevala… - American journal of …, 2008 - journals.lww.com
Objectives: Early testing of aerosolized sargramostim therapy demonstrated anecdotal
clinical responses in patients with metastatic melanoma associated with emergence of …
clinical responses in patients with metastatic melanoma associated with emergence of …
Clinical applications of colony-stimulating factors: a historical perspective
RK Sylvester - American journal of health-system pharmacy, 2002 - academic.oup.com
The development of the therapeutic roles of filgrastim and sargramostim over the past
decade is reviewed. Filgrastim, a recombinant granulocyte colony-stimulating factor (G …
decade is reviewed. Filgrastim, a recombinant granulocyte colony-stimulating factor (G …
Emerging applications of recombinant human granulocyte-macrophage colony-stimulating factor
JO Armitage - Blood, The Journal of the American Society of …, 1998 - ashpublications.org
CLINICAL INDICATIONS for use of recombinant human granulocyte-macrophage colony-
stimulating factor (rHuGM-CSF) have expanded considerably since the drug first became …
stimulating factor (rHuGM-CSF) have expanded considerably since the drug first became …