Ischemia/reperfusion (IR) injury contributes to disability and mortality worldwide. Due to the
complicated mechanisms and lack of proper therapeutic targets, few interventions are …

Apoptosis, necrosis and autophagy-dependent cell death are the three major types of cell
death. Traditionally, necrosis is thought as a passive and unregulated form of cell death …

Interference with regulated necrosis for clinical purposes carries broad therapeutic
relevance and, if successfully achieved, has a potential to revolutionize everyday clinical …

Ischemia-reperfusion injury is associated with serious clinical manifestations, including
myocardial hibernation, acute heart failure, cerebral dysfunction, gastrointestinal …

Ischemic stroke is one of the major causes of morbidity and mortality, affecting millions of
people worldwide. Inevitably, the interruption of cerebral blood supply after ischemia may …

Prolonged ischemia can result in apoptotic death of vascular endothelial cells and lead to
ischemic vascular diseases including vascular dementia, arteriosclerosis and brain oedema …

Ischemia-reperfusion (I/R) injury, uncommon among patients suffering from myocardial
infarction, stroke, or acute kidney injury, can result in cell death and organ dysfunction …

Background: Oxidative stress-induced endothelial cell death, such as apoptosis and
autophagy, plays a critical role in ischemia-reperfusion injury. Protocatechualdehyde (PCA) …

The endothelium is a single layer of epithelium covering the surface of the vascular system,
and it represents a physical barrier between the blood and vessel wall that plays an …

Ischemia reperfusion-induced tissue injuries and organ failure represent the major causes of
postoperative mortality and morbidity. Oxidative stress-mediated cell death plays a vital role …