Hesperetin, a citrus flavonoid, attenuates LPS-induced neuroinflammation, apoptosis and memory impairments by modulating TLR4/NF-κB signaling

T Muhammad, M Ikram, R Ullah, SU Rehman, MO Kim - Nutrients, 2019 - mdpi.com
Glial activation and neuroinflammation play significant roles in apoptosis as well as in the
development of cognitive and memory deficits. Neuroinflammation is also a critical feature in …

Neuroprotective effect of quercetin against the detrimental effects of LPS in the adult mouse brain

A Khan, T Ali, SU Rehman, MS Khan, SI Alam… - Frontiers in …, 2018 - frontiersin.org
Chronic neuroinflammation is responsible for multiple neurodegenerative diseases, such as
Alzheimer's disease, Parkinson's disease, and Huntington's disease. Lipopolysaccharide …

Eriodictyol alleviates lipopolysaccharide‐triggered oxidative stress and synaptic dysfunctions in BV‐2 microglial cells and mouse brain

P He, S Yan, X Wen, S Zhang, Z Liu… - Journal of Cellular …, 2019 - Wiley Online Library
Oxidative stress takes part in the development of the neurodegenerative disease.
Eriodictyol, a flavonoid, commonly presents in citrus fruits, which was well‐known for its …

Hesperetin inhibits neuroinflammation on microglia by suppressing inflammatory cytokines and MAPK pathways

SH Jo, ME Kim, JH Cho, Y Lee, J Lee, YD Park… - Archives of pharmacal …, 2019 - Springer
Neuroinflammation is a specific or nonspecific immunological reaction in the central nervous
system that is induced by microglia activation. Appropriate regulation of activated microglial …

Eriodictyol attenuates LPS-induced neuroinflammation, amyloidogenesis, and cognitive impairments via the inhibition of NF-κB in male C57BL/6J mice and BV2 …

P He, S Yan, J Zheng, Y Gao, S Zhang… - Journal of agricultural …, 2018 - ACS Publications
Eriodictyol, a natural flavonoid mainly distributed in citrus fruits and peanut, has been well-
documented with possession of excellent anti-inflammatory, antioxidant, and anticancer …

Hesperetin confers neuroprotection by regulating Nrf2/TLR4/NF-κB signaling in an Aβ mouse model

M Ikram, T Muhammad, SU Rehman, A Khan… - Molecular …, 2019 - Springer
Hesperetin is a bioactive flavonoid in the body, produced from hesperidin. No
comprehensive studies have shown its protective effects in neurodegenerative disorders …

Kaempferol attenuates LPS-induced striatum injury in mice involving anti-neuroinflammation, maintaining BBB integrity, and down-regulating the HMGB1/TLR4 …

YL Yang, X Cheng, WH Li, M Liu, YH Wang… - International Journal of …, 2019 - mdpi.com
Neuroinflammation has been demonstrated to be linked with Parkinson's disease (PD),
Alzheimer's disease, and cerebral ischemia. Our previous investigation had identified that …

Hesperidin alleviates chronic restraint stress and lipopolysaccharide-induced Hippocampus and Frontal cortex damage in mice: Role of TLR4/NF-κB, p38 MAPK/JNK …

M Kwatra, S Ahmed, B Gawali, SR Panda… - Neurochemistry …, 2020 - Elsevier
Stress and lipopolysaccharide (LPS) animal models are used for screening antidepressants
and anxiolytic drugs. However, the lacunae for their combination (Restraint stress; RS and …

Attenuation of aluminum chloride-induced neuroinflammation and caspase activation through the AKT/GSK-3β pathway by hesperidin in wistar rats

A Justin-Thenmozhi, M Dhivya Bharathi… - Neurotoxicity …, 2018 - Springer
Hesperidin, a flavanoglycone abundantly present in citrus fruits, is reported to have
antioxidant, anti-inflammatory, and neuroprotective properties. Previous reports from our …

Phloridzin attenuates lipopolysaccharide-induced cognitive impairment via antioxidant, anti-inflammatory and neuromodulatory activities

SP Kamdi, A Raval, KT Nakhate - Cytokine, 2021 - Elsevier
Background Lipopolysaccharide (LPS) is known to produce neuroinflammation and memory
impairment. Although phloridzin (a phenolic phytoconstituent) shows antioxidant-and anti …