Levamisole—a toxic adulterant in illicit drug preparations: a review

KM Midthun, LS Nelson, BK Logan - Therapeutic Drug Monitoring, 2021 - journals.lww.com
Discovered in the 1960s, the common anthelminthic levamisole has seen widespread use in
veterinary applications. Its use rapidly expanded thereafter to include human medical …

Levamisole-adulterated cocaine: two fatal case reports and evaluation of possible cocaine toxicity potentiation

F Indorato, G Romano, N Barbera - Forensic science international, 2016 - Elsevier
Levamisole has been identified as a cocaine adulterant in the United States since 2002.
Although there is a variation in the percentage of levamisole in cocaine samples between …

Adverse effects of levamisole in cocaine users: a review and risk assessment

TM Brunt, J van den Berg, E Pennings, B Venhuis - Archives of Toxicology, 2017 - Springer
The immunomodulatory adjuvant and antihelminth levamisole is increasingly used as an
adulterant in cocaine worldwide. An accumulating body of clinical and toxicological literature …

Detection of levamisole exposure in cocaine users by liquid chromatography-tandem mass spectrometry

KL Lynch, SS Dominy, J Graf… - Journal of analytical …, 2011 - academic.oup.com
Levamisole, a veterinary antihelminthic, was recently recognized as an adulterant in cocaine
and is known to cause severe adverse reactions in some cocaine users. Because of the …

Bioanalytical methods for quantitation of levamisole, a widespread cocaine adulterant

JL Shea - Clinical Chemistry and Laboratory Medicine (CCLM), 2013 - degruyter.com
Levamisole is an anthelminthic that was first used as a de-worming agent in humans and
animals. It has also been used to treat inflammatory conditions as well as certain types of …

Levamisole in cocaine: unexpected news from an old acquaintance

A Larocque, RS Hoffman - Clinical Toxicology, 2012 - Taylor & Francis
Levamisole is a pharmaceutical with anthelminthic and immunomodulatory properties that
was previously used in both animals and humans to treat inflammatory conditions and …

Levamisole in illicit trafficking cocaine seized: a one-year study

S Martello, M Pieri, C Ialongo, S Pignalosa… - … of psychoactive drugs, 2017 - Taylor & Francis
Cocaine use is increasing around the world and its purity is frequently altered through
dilution, substitution, contamination, and adulteration. Sugars, talc, starch, and carbonates …

Levamisole: a dangerous new cocaine adulterant

A Chang, J Osterloh, J Thomas - Clinical Pharmacology & …, 2010 - Wiley Online Library
Levamisole has increasingly been discovered in street cocaine as an adulterant. Recent
reports have linked levamisole in street cocaine to agranulocytosis in cocaine users. It is …

Adverse reactions with levamisole vary according to its indications and misuse: A systematic pharmacovigilance study

JT Campillo, C Eiden, M Boussinesq… - British Journal of …, 2022 - Wiley Online Library
Levamisole was initially prescribed for the treatment of intestinal worms. Because of
immunomodulatory properties, levamisole has been used in inflammatory pathologies and …

Immune-mediated agranulocytosis caused by the cocaine adulterant levamisole: a case for reactive metabolite (s) involvement

A Wolford, TS McDonald, H Eng, S Hansel… - Drug Metabolism and …, 2012 - ASPET
The United States Public Health Service Administration is alerting medical professionals that
a substantial percentage of cocaine imported into the United States is adulterated with …