OBJECTIVE: Sleep deprivation has been shown to have an antidepressant benefit in a
subgroup of depressed patients. Functional imaging studies by the authors and others have …

Sleep deprivation has been shown to have a rapid, nonpharmacologic antidepressant effect
in studies involving over 1,500 patients (1–3). In normal subjects sleep deprivation is …

OBJECTIVE: The treatment of geriatric depression is complicated by a variable and delayed
response to antidepressant treatment. The present study was undertaken to test the …

The antidepressant and cerebral metabolic effects of total sleep deprivation (TSD) or partial
sleep deprivation (PSD) for one night has been studied with functional neuroimaging in …

This paper reviews the functional brain imaging studies in depressed patients treated with
sleep deprivation. Sleep deprivation is an excellent experimental model of antidepressant …

Background: Depression is characterized by several sleeprelated abnormalities shortly
before and after sleep onset, such as prolonged sleep latency, loss of stage 3-4 sleep …

Background Depression is associated with sleep disturbances, including alterations in non–
rapid eye movement (NREM) sleep. Non–rapid eye movement sleep is associated with …

OBJECTIVE: Sleep disturbances characterize depression and may reflect the abnormal
persistence of brain activity from wakefulness into non-REM sleep. The goal of this study …

Based on recent functional brain imaging studies of healthy human REM sleep, we
hypothesized that alterations in REM sleep in mood disorder patients reflect a functional …

Background Depression is associated with sleep disturbances, including alterations in rapid
eye movement (REM) sleep, that may relate to the neurobiology of the disorder. Given that …