[HTML][HTML] The development of New Delhi metallo-β-lactamase-1 inhibitors since 2018

X Gu, M Zheng, L Chen, H Li - Microbiological Research, 2022 - Elsevier
New Delhi metallo-β-lactamase-1 (NDM-1) can hydrolyze almost all antibiotics of the β-
lactam group, resulting in the generation of multidrug resistant bacteria. Besides its broad …

Ten years with New Delhi metallo-β-lactamase-1 (NDM-1): from structural insights to inhibitor design

P Linciano, L Cendron, E Gianquinto… - ACS infectious …, 2018 - ACS Publications
The worldwide emergence of New Delhi metallo-β-lactamase-1 (NDM-1) as a
carbapenemase able to hydrolyze nearly all available β-lactam antibiotics has characterized …

Efforts towards the inhibitor design for New Delhi metallo-beta-lactamase (NDM-1)

KCN Venkata, M Ellebrecht, SK Tripathi - European journal of medicinal …, 2021 - Elsevier
Antimicrobial stewardship is imperative when treating bacterial infections because the
misuse and overuse of antibiotics have caused pathogens to develop life-threatening …

New Delhi metallo-β-lactamase-1 inhibitors for combating antibiotic drug resistance: Recent developments

AS Grewal, K Thapa, N Sharma, S Singh - Medicinal Chemistry Research, 2020 - Springer
The most common mechanism of the resistance to β-lactam antibiotics is the
expIdentification of cisplatin and palladiuression of β-lactamases, which can hydrolyze the β …

New Delhi metallo-β-lactamase-1: structure, inhibitors and detection of producers

PW Groundwater, S Xu, F Lai, L Varadi… - Future medicinal …, 2016 - Taylor & Francis
Since its discovery in 2008, New Delhi metallo-β-lactamase-1 (NDM-1)-producing
Enterobacteriaceae have disseminated globally, facilitated predominantly by gut …

Potential inhibitors against NDM-1 type metallo-β-lactamases: an overview

S Sharma, S Sharma, PP Singh… - Microbial Drug Resistance, 2020 - liebertpub.com
A new member of the class metallo-β-lactamase (MBL), New Delhi metallo-beta-lactamase 1
(NDM-1) has emerged recently as a leading threat to the treatment of infections that have …

[HTML][HTML] Potential inhibitors designed against NDM-1 type metallo-β-lactamases: an attempt to enhance efficacies of antibiotics against multi-drug-resistant bacteria

AU Khan, A Ali, Danishuddin, G Srivastava… - Scientific reports, 2017 - nature.com
NDM-1 and its variants are the most prevalent types of metallo-β-lactamases, hydrolyze
almost all antibiotics of β-lactam group leading to multiple-drug resistance in bacteria. No …

Discovery of NDM-1 inhibitors from natural products

C Shi, J Chen, B Xiao, X Kang, X Lao… - Journal of global …, 2019 - Elsevier
Objectives Human health is seriously threatened by metallo-β-lactamase (MBL)-mediated
bacterial antimicrobial resistance, among which New Delhi metallo-β-lactamase 1 (NDM-1) …

Structure-based virtual screening for the discovery of novel inhibitors of New Delhi metallo-β-lactamase-1

F Spyrakis, G Celenza, F Marcoccia… - ACS medicinal …, 2018 - ACS Publications
Bacterial resistance has become a worldwide concern after the emergence of metallo-β-
lactamases (MBLs). They represent one of the major mechanisms of bacterial resistance …

[HTML][HTML] Risedronate and methotrexate are high-affinity inhibitors of New Delhi Metallo-β-Lactamase-1 (NDM-1): a drug repurposing approach

G Muteeb, A Alsultan, M Farhan, M Aatif - Molecules, 2022 - mdpi.com
Bacteria expressing New Delhi metallo-β-lactamase-1 (NDM-1) can hydrolyze β-lactam
antibiotics (penicillins, cephalosporins, and carbapenems) and, thus, mediate multidrug …