Mechanisms underpinning the dysfunctional immune response in severe acute respiratory
syndrome coronavirus 2 infection are elusive. We analyzed single-cell transcriptomes and T …

Our understanding of protective versus pathological immune responses to SARS-CoV-2, the
virus that causes coronavirus disease 2019 (COVID-19), is limited by inadequate profiling of …

Abstract In coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection, the relationship between disease severity …

There is an urgent need to better understand the pathophysiology of Coronavirus disease
2019 (COVID-19), the global pandemic caused by SARS-CoV-2, which has infected more …

Abstract Analysis of human blood immune cells provides insights into the coordinated
response to viral infections such as severe acute respiratory syndrome coronavirus 2, which …

Severe COVID-19 causes profound immune perturbations, but pre-infection immune
signatures contributing to severe COVID-19 remain unknown. Genome-wide association …

Recent studies have demonstrated immunologic dysfunction in severely ill coronavirus
disease 2019 (COVID-19) patients. We use single-cell RNA sequencing (scRNA-seq) to …

The determinants of severe COVID-19 in healthy adults are poorly understood, which limits
the opportunity for early intervention. We present a multiomic analysis using machine …

Objectives COVID-19 has caused a large global pandemic. Patients with COVID-19
exhibited considerable variation in disease behavior. Pervious genome-wide association …

The mortality risk of coronavirus disease 2019 (COVID-19) patients has been linked to the
cytokine storm caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …