Antibody-dependent cellular cytotoxicity response to SARS-CoV-2 in COVID-19 patients

Y Yu, M Wang, X Zhang, S Li, Q Lu, H Zeng… - Signal transduction and …, 2021 - nature.com
Antibody-dependent cellular cytotoxicity (ADCC) responses to viral infection are a form of
antibody regulated immune responses mediated through the Fc fragment. Whether severe …

Presence of antibody-dependent cellular cytotoxicity (ADCC) against SARS-CoV-2 in COVID-19 plasma

FY Tso, SJ Lidenge, LK Poppe, PB Peña, SR Privatt… - PLoS …, 2021 - journals.plos.org
Background Neutralizing-antibody (nAb) is the major focus of most ongoing COVID-19
vaccine trials. However, nAb response against SARS-CoV-2, when present, decays rapidly …

Decay of Fc-dependent antibody functions after mild to moderate COVID-19

WS Lee, KJ Selva, SK Davis, BD Wines, A Reynaldi… - Cell Reports …, 2021 - cell.com
The capacity of antibodies to engage with immune cells via the Fc region is important in
preventing and controlling many infectious diseases. The evolution of such antibodies …

Multiple routes of antibody-dependent enhancement of SARS-CoV-2 infection

K Okuya, T Hattori, T Saito, Y Takadate… - Microbiology …, 2022 - Am Soc Microbiol
Antibody-dependent enhancement (ADE) of infection is generally known for many viruses. A
potential risk of ADE in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

COVID-19 severity is associated with differential antibody Fc-mediated innate immune functions

OS Adeniji, LB Giron, M Purwar, NF Zilberstein… - MBio, 2021 - Am Soc Microbiol
Beyond neutralization, antibodies binding to their Fc receptors elicit several innate immune
functions including antibody-dependent complement deposition (ADCD), antibody …

Antibody-dependent enhancement of SARS-CoV-2 infection is mediated by the IgG receptors FcγRIIA and FcγRIIIA but does not contribute to aberrant cytokine …

T Maemura, M Kuroda, T Armbrust, S Yamayoshi… - MBio, 2021 - Am Soc Microbiol
ABSTRACT The coronavirus disease 2019 (COVID-19) pandemic has raised concerns
about the detrimental effects of antibodies. Antibody-dependent enhancement (ADE) of …

Two different antibody-dependent enhancement (ADE) risks for SARS-CoV-2 antibodies

DO Ricke - Frontiers in immunology, 2021 - frontiersin.org
COVID-19 (SARS-CoV-2) disease severity and stages varies from asymptomatic, mild flu-
like symptoms, moderate, severe, critical, and chronic disease. COVID-19 disease …

Impaired cellular immunity to SARS-CoV-2 in severe COVID-19 patients

L Ni, ML Cheng, Y Feng, H Zhao, J Liu, F Ye… - Frontiers in …, 2021 - frontiersin.org
The high infection rate and rapid spread of severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) make it a world-wide pandemic. Individuals infected by the virus exhibited …

Beyond neutralization: Fc-dependent antibody effector functions in SARS-CoV-2 infection

A Zhang, HD Stacey, MR D'Agostino, Y Tugg… - Nature Reviews …, 2023 - nature.com
Neutralizing antibodies are known to have a crucial role in protecting against SARS-CoV-2
infection and have been suggested to be a useful correlate of protection for vaccine clinical …

Potent SARS-CoV-2-specific T cell immunity and low anaphylatoxin levels correlate with mild disease progression in COVID-19 patients

E Lafon, G Diem, C Witting, V Zaderer… - Frontiers in …, 2021 - frontiersin.org
T cells play a fundamental role in the early control and clearance of many viral infections of
the respiratory system. In SARS-CoV-2-infected individuals, lymphopenia with drastically …