Susceptibility to schizophrenia is inversely correlated with general cognitive ability at both
the phenotypic and the genetic level. Paradoxically, a modest but consistent positive genetic …

Breakthroughs in genomics have begun to unravel the genetic architecture of schizophrenia
risk, providing methods for quantifying schizophrenia polygenic risk based on common …

There is evidence for genetic overlap between cognitive abilities and schizophrenia (SCZ),
and genome-wide association studies (GWAS) demonstrate that both SCZ and general …

Neurocognitive abilities constitute complex traits with considerable heritability. Impaired
neurocognition is typically observed in schizophrenia (SZ), whereas convergent evidence …

General cognitive (intelligence) function is substantially heritable, and is a major
determinant of economic and health-related life outcomes. Cognitive impairments and …

Schizophrenia is a multifactorial disease associated with widespread cognitive impairment.
Although cognitive deficits are one of the factors most strongly associated with functional …

Psychotic disorders including schizophrenia are commonly accompanied by cognitive
deficits. Recent studies have reported negative genetic correlations between schizophrenia …

Large-scale genomic studies of schizophrenia have identified hundreds of genetic loci
conferring risk to the disorder. This progress offers an important route toward defining the …

Cognitive impairment is a core feature of schizophrenia but there is limited understanding of
the genetic relationship between cognition in the general population and schizophrenia. We …

The complex nature of human cognition has resulted in cognitive genomics lagging behind
many other fields in terms of gene discovery using genome-wide association study (GWAS) …