Structure and mutations of SARS-CoV-2 spike protein: a focused overview

R Mehra, KP Kepp - ACS Infectious Diseases, 2021 - ACS Publications
The spike protein (S-protein) of SARS-CoV-2, the protein that enables the virus to infect
human cells, is the basis for many vaccines and a hotspot of concerning virus evolution …

[HTML][HTML] Flexible, functional, and familiar: characteristics of SARS-CoV-2 spike protein evolution

DS Saputri, S Li, FJ Van Eerden, J Rozewicki… - Frontiers in …, 2020 - frontiersin.org
The SARS-CoV-2 S protein is a major point of interaction between the virus and the human
immune system. As a consequence, the S protein is not a static target but undergoes rapid …

[HTML][HTML] Structural dynamics of the SARS-CoV-2 spike protein: A 2-year retrospective analysis of SARS-CoV-2 variants (from Alpha to Omicron) reveals an early …

P Guérin, N Yahi, F Azzaz, H Chahinian, JM Sabatier… - Molecules, 2022 - mdpi.com
We analyzed the epitope evolution of the spike protein in 1,860,489 SARS-CoV-2 genomes.
The structural dynamics of these epitopes was determined by molecular modeling …

Structure of SARS-CoV-2 spike protein

J Zhang, T Xiao, Y Cai, B Chen - Current opinion in virology, 2021 - Elsevier
The COVID-19 (coronavirus disease 2019) pandemic, caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), has led to loss of human life in millions and …

[HTML][HTML] Cryo-electron microscopy structures of the N501Y SARS-CoV-2 spike protein in complex with ACE2 and 2 potent neutralizing antibodies

X Zhu, D Mannar, SS Srivastava, AM Berezuk… - PLoS …, 2021 - journals.plos.org
The recently reported “UK variant”(B. 1.1. 7) of SARS-CoV-2 is thought to be more infectious
than previously circulating strains as a result of several changes, including the N501Y …

[HTML][HTML] Structural and functional analysis of the D614G SARS-CoV-2 spike protein variant

L Yurkovetskiy, X Wang, KE Pascal, C Tomkins-Tinch… - Cell, 2020 - cell.com
Summary The SARS-CoV-2 spike (S) protein variant D614G supplanted the ancestral virus
worldwide, reaching near fixation in a matter of months. Here we show that D614G was …

[HTML][HTML] Structural and functional insights into the spike protein mutations of emerging SARS-CoV-2 variants

D Gupta, P Sharma, M Singh, M Kumar… - Cellular and Molecular …, 2021 - Springer
Since the emergence of the first case of coronavirus disease 2019 (COVID-19), caused by
severe acute respiratory syndrome coronavirus (SARS-CoV-2), the viral genome has …

[HTML][HTML] Evolution of the SARS-CoV-2 spike protein in the human host

AG Wrobel, DJ Benton, C Roustan, A Borg… - Nature …, 2022 - nature.com
Recently emerged variants of SARS-CoV-2 contain in their surface spike glycoproteins
multiple substitutions associated with increased transmission and resistance to neutralising …

[HTML][HTML] Structural basis for the different states of the spike protein of SARS-CoV-2 in complex with ACE2

R Yan, Y Zhang, Y Li, F Ye, Y Guo, L Xia, X Zhong… - Cell research, 2021 - nature.com
Dear Editor, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a
severe threat to global health. 1 The spike (S) protein on the surface of SARS-CoV-2 exploits …

[HTML][HTML] SARS-CoV-2 spike protein: flexibility as a new target for fighting infection

CL Pierri - Signal Transduction and Targeted Therapy, 2020 - nature.com
The spike protein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is
crucial for the infection because it mediates the virus entry into human host-cells, through …