Organisms utilize gene regulatory networks (GRN) to make fate decisions, but the regulatory
mechanisms of transcription factors (TF) in GRNs are exceedingly intricate. A longstanding …

The process of cell fate determination has been depicted intuitively as cells travelling and
resting on a rugged landscape, which has been probed by various theoretical studies …

Time-specific modulation of gene expression during differentiation by transcription factors
promotes cell diversity. However, estimating their dynamic regulatory activity at the single …

Stem cells can precisely and robustly undergo cellular differentiation and lineage
commitment, referred to as stemness. However, how the gene network underlying stemness …

Proper cell fate determination is largely orchestrated by complex gene regulatory networks
centered around transcription factors. However, experimental elucidation of key transcription …

Gene regulatory networks (GRNs) play a central role in cellular decision-making.
Understanding their structure and how it impacts their dynamics constitutes thus a …

Both microbes and multicellular organisms actively regulate their cell fate determination to
cope with changing environments or to ensure proper development. Here, we use synthetic …

Gene regulatory networks (GRNs) fulfill the essential function of maintaining the stability of
cellular differentiation states by sustaining lineage-specific gene expression, while driving …

Background The image of the" epigenetic landscape", with a series of branching valleys and
ridges depicting stable cellular states and the barriers between those states, has been a …

Large amounts of effort have been invested in trying to understand how a single genome is
able to specify the identity of hundreds of cell types. Inspired by some aspects of …