The legacy of mRNA engineering: A lineup of pioneers for the Nobel Prize

M Janowski, A Andrzejewska - Molecular Therapy-Nucleic Acids, 2022 - cell.com
mRNA is like Hermes, delivering the genetic code to cellular construction sites, so it has long
been of interest, but only to a small group of scientists, and only demonstrating its …

Cell engineering with synthetic messenger RNA

PM Rabinovich, SM Weissman - Synthetic Messenger RNA and Cell …, 2013 - Springer
Abstract mRNA has become an important alternative to DNA as a tool for cell
reprogramming. To be expressed, exogenous DNA must be transmitted through the cell …

mRNA–a game changer in regenerative medicine, cell-based therapy and reprogramming strategies

O Chabanovska, AM Galow, R David… - Advanced Drug Delivery …, 2021 - Elsevier
After thirty years of intensive research shaping and optimizing the technology, the approval
of the first mRNA-based formulation by the EMA and FDA in order to stop the COVID-19 …

Messenger RNA-based therapeutics and vaccines: what's beyond COVID-19?

D Li, C Liu, Y Li, R Tenchov, JM Sasso… - ACS pharmacology & …, 2023 - ACS Publications
With the rapid success in the development of mRNA vaccines against COVID-19 and with a
number of mRNA-based drugs ahead in the pipelines, mRNA has catapulted to the forefront …

RNA therapeutics: A healthcare paradigm shift

SK Niazi - Biomedicines, 2023 - mdpi.com
COVID-19 brought about the mRNA vaccine and a paradigm shift to a new mode of treating
and preventing diseases. Synthetic RNA products are a low-cost solution based on a novel …

Recent advances in modified cap analogs: synthesis, biochemical properties, and mRNA based vaccines

M Shanmugasundaram, A Senthilvelan… - The Chemical …, 2022 - Wiley Online Library
The recent FDA approval of the mRNA vaccine for severe acute respiratory syndrome
coronavirus (SARS‐CoV‐2) emphasizes the importance of mRNA as a powerful tool for …

Therapeutic mRNA engineering from head to tail

L Jia, SB Qian - Accounts of Chemical Research, 2021 - ACS Publications
Conspectus Synthetic messenger RNA (mRNA), once delivered into cells, can be readily
translated into proteins by ribosomes, which do not distinguish exogenous mRNAs from …

[HTML][HTML] The future in an RNA molecule: from mRNA vaccines to therapeutics–An interview with Drew Weissman

D Ruffell - Febs Letters, 2021 - ncbi.nlm.nih.gov
The COVID-19 pandemic created an unprecedented state of emergency, during which
medical doctors struggled to save lives, and scientists worked feverishly to study the virus …

The forerunners and successful partnerships behind the BioNTech mRNA vaccine

I Aygün, J Barciszewski - Journal of Applied Genetics, 2024 - Springer
The discovery of nucleic acids stands as a paramount achievement in the history of scientific
endeavors. By applying transformative advancements in the fields of chemistry and physics …

Design, assembly, production, and transfection of synthetic modified mRNA

S Oh, JA Kessler - Methods, 2018 - Elsevier
Proteins are drivers of cell functions and are targets of many therapies. Exogenous protein
expression techniques, therefore, have been essential for research and medicine. The most …