PM Rabinovich, SM Weissman - Synthetic Messenger RNA and Cell …, 2013 - Springer
Abstract mRNA has become an important alternative to DNA as a tool for cell reprogramming. To be expressed, exogenous DNA must be transmitted through the cell …
O Chabanovska, AM Galow, R David… - Advanced Drug Delivery …, 2021 - Elsevier
After thirty years of intensive research shaping and optimizing the technology, the approval of the first mRNA-based formulation by the EMA and FDA in order to stop the COVID-19 …
D Li, C Liu, Y Li, R Tenchov, JM Sasso… - ACS pharmacology & …, 2023 - ACS Publications
With the rapid success in the development of mRNA vaccines against COVID-19 and with a number of mRNA-based drugs ahead in the pipelines, mRNA has catapulted to the forefront …
COVID-19 brought about the mRNA vaccine and a paradigm shift to a new mode of treating and preventing diseases. Synthetic RNA products are a low-cost solution based on a novel …
M Shanmugasundaram, A Senthilvelan… - The Chemical …, 2022 - Wiley Online Library
The recent FDA approval of the mRNA vaccine for severe acute respiratory syndrome coronavirus (SARS‐CoV‐2) emphasizes the importance of mRNA as a powerful tool for …
L Jia, SB Qian - Accounts of Chemical Research, 2021 - ACS Publications
Conspectus Synthetic messenger RNA (mRNA), once delivered into cells, can be readily translated into proteins by ribosomes, which do not distinguish exogenous mRNAs from …
The COVID-19 pandemic created an unprecedented state of emergency, during which medical doctors struggled to save lives, and scientists worked feverishly to study the virus …
I Aygün, J Barciszewski - Journal of Applied Genetics, 2024 - Springer
The discovery of nucleic acids stands as a paramount achievement in the history of scientific endeavors. By applying transformative advancements in the fields of chemistry and physics …
Proteins are drivers of cell functions and are targets of many therapies. Exogenous protein expression techniques, therefore, have been essential for research and medicine. The most …