Immune Responses Following Administration of Whole Gamma Irradiated SARS-CoV-2 Vaccine Stabilized With Disaccharide Trehalose on Syrian Hamster Model

F Motamedi-Sedeh, A Khorasani, M Lotfi, SM Moosavi… - 2023 - researchsquare.com
Background The SARS-CoV-2 virus is the causative agent of the emerging respiratory
zoonosis disease. One of the most important requirements for the control of emerging …

Absence of vaccine-enhanced disease with unexpected positive protection against SARS-CoV-2 by inactivated vaccine given within three days of virus challenge in …

C Li, YX Chen, FF Liu, AC Lee, Y Zhao, ZH Ye, JP Cai… - Clin Infect Dis, 2021 - hero.epa.gov
BACKGROUND: Mass vaccination against severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) is ongoing amidst widespread transmission during the Coronavirus Disease …

Absence of vaccine-enhanced disease with unexpected positive protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by inactivated …

C Li, YX Chen, FF Liu, ACY Lee, Y Zhao… - Clinical Infectious …, 2021 - academic.oup.com
Background Mass vaccination against severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) is ongoing amidst widespread transmission during the coronavirus disease …

Preclinical efficacy and safety analysis of gamma-irradiated inactivated SARS-CoV-2 vaccine candidates

G Sir Karakus, C Tastan, D Dilek Kancagi… - Scientific reports, 2021 - nature.com
COVID-19 outbreak caused by SARS-CoV-2 created an unprecedented health crisis since
there is no vaccine for this novel virus. Therefore, SARS-CoV-2 vaccines have become …

Immunogenicity and protective efficacy of BBV152, whole virion inactivated SARS-CoV-2 vaccine candidates in the Syrian hamster model

S Mohandas, PD Yadav, A Shete-Aich, P Abraham… - IScience, 2021 - cell.com
The availability of a safe and effective vaccine would be the eventual measure to deal with
severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) threat. Here, we have …

Immunogenicity and safety of an inactivated SARS-CoV-2 vaccine: preclinical studies

A Kandeil, A Mostafa, RR Hegazy, R El-Shesheny… - Vaccines, 2021 - mdpi.com
Since the emergence of SARS-CoV-2 at the end of 2019, 64 candidate vaccines are in
clinical development and 173 are in the pre-clinical phase. Five types of vaccines are …

Evaluation of Immunogenicity and Clinical Protection of SARS-CoV-2 S1 and N Antigens in Syrian Golden Hamster

Z Niu, X Li, Y Gao, L Wang, S Fan, X Xu, G Jiang, P Cui… - Vaccines, 2022 - mdpi.com
The novel coronavirus (SARS-CoV-2) epidemic continues to be a global public crisis
affecting human health. Many research groups are developing different types of vaccines to …

Broad humoral immunity generated in mice by a formulation composed of two antigens from the Delta variant of SARS-CoV-2

Y Lobaina, R Chen, E Suzarte, P Ai, V Huerta, C Tan… - Archives of …, 2023 - Springer
Due to the rapid development of new variants of SARS-CoV-2 as well as the real threat of
new coronavirus zoonosis events, the development of a preventive vaccine with a broader …

Immunological Response to Subcutaneous and Intranasal Administration of SARS-CoV-2 Spike Protein in Mice

M Kinoshita, K Muranishi, K Kawaguchi, K Sudo… - Vaccines, 2024 - mdpi.com
In novel coronavirus infection (COVID-19), the outbreak of acute lung injury due to trans-
airway infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is …

Development of Inactivated FAKHRAVAC® Vaccine against SARS-CoV-2 Virus: Preclinical Study in Animal Models

S Ghasemi, K Naderi Saffar, F Ebrahimi, P Khatami… - Vaccines, 2021 - mdpi.com
The recent viral infection disease pandemic, caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), has resulted in a global public health crisis. Iran, as one of the …