Immune correlates of protection by mRNA-1273 vaccine against SARS-CoV-2 in nonhuman primates

KS Corbett, MC Nason, B Flach, M Gagne, S O'Connell… - Science, 2021 - science.org
INTRODUCTION Mass vaccination against severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) offers the most efficient public health intervention to control the COVID-19 …

Protection against SARS-CoV-2 Beta variant in mRNA-1273 vaccine–boosted nonhuman primates

KS Corbett, M Gagne, DA Wagner, S O'Connell… - Science, 2021 - science.org
Neutralizing antibody responses gradually wane against several variants of concern (VOCs)
after vaccination with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

Immune correlates of protection by mRNA-1273 immunization against SARS-CoV-2 infection in nonhuman primates

KS Corbett, MC Nason, B Flach, M Gagne, S O'Connell… - BioRxiv, 2021 - biorxiv.org
Immune correlates of protection can be used as surrogate endpoints for vaccine efficacy.
The nonhuman primate (NHP) model of SARS-CoV-2 infection replicates key features of …

Efficacy of mRNA-1273 and Novavax ancestral or BA. 1 spike booster vaccines against SARS-CoV-2 BA. 5 infection in nonhuman primates

NK Routhu, SD Stampfer, L Lai, A Akhtar, X Tong… - Science …, 2023 - science.org
Omicron SARS-CoV-2 variants escape vaccine-induced neutralizing antibodies and cause
nearly all current COVID-19 cases. Here, we compared the efficacy of three booster …

SARS-CoV-2 infection protects against rechallenge in rhesus macaques

A Chandrashekar, J Liu, AJ Martinot, K McMahan… - Science, 2020 - science.org
An understanding of protective immunity to severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) is critical for vaccine and public health strategies aimed at ending the global …

Immunogenicity of clinically relevant SARS-CoV-2 vaccines in nonhuman primates and humans

PJ Klasse, DF Nixon, JP Moore - Science advances, 2021 - science.org
Multiple preventive vaccines are being developed to counter the coronavirus disease 2019
pandemic. The leading candidates have now been evaluated in nonhuman primates (NHPs) …

Evaluation of the mRNA-1273 vaccine against SARS-CoV-2 in nonhuman primates

KS Corbett, B Flynn, KE Foulds… - … England Journal of …, 2020 - Mass Medical Soc
Background Vaccines to prevent coronavirus disease 2019 (Covid-19) are urgently needed.
The effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines on …

Protective activity of mRNA vaccines against ancestral and variant SARS-CoV-2 strains

B Ying, B Whitener, LA VanBlargan… - Science translational …, 2021 - science.org
Although mRNA vaccines encoding the spike protein of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) prevent COVID-19, the emergence of new viral variants …

Boosting immunity to COVID-19 vaccines

JA Juno, AK Wheatley - Nature medicine, 2021 - nature.com
Boosting immunity to COVID-19 vaccines | Nature Medicine Skip to main content Thank you for
visiting nature.com. You are using a browser version with limited support for CSS. To obtain the …

Immune correlates analysis of the mRNA-1273 COVID-19 vaccine efficacy clinical trial

PB Gilbert, DC Montefiori, AB McDermott, Y Fong… - Science, 2022 - science.org
In the coronavirus efficacy (COVE) phase 3 clinical trial, vaccine recipients were assessed
for neutralizing and binding antibodies as correlates of risk for COVID-19 disease and as …