The main proteases (Mpro), also termed 3‐chymotrypsin‐like proteases (3CLpro), are a
class of highly conserved cysteine hydrolases in β‐coronaviruses. Increasing evidence has …

Effective, safe, and pharmacokinetically suitable drugs are urgently needed to curb the
ongoing COVID-19 pandemic. The main protease or 3C-like protease (Mpro or 3CLpro) of …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), similar to SARS-CoV and
Middle East respiratory syndrome coronavirus (MERS-CoV), which belong to the same …

The main protease (Mpro) of SARS-CoV-2 is a validated antiviral drug target. Several Mpro
inhibitors have been reported with potent enzymatic inhibition and cellular antiviral activity …

3CLpro is an attractive target for the treatment of COVID-19. Using the scaffold hopping
strategy, we identified a potent inhibitor of 3CLpro (3a) that contains a thiocyanate moiety as …

The main protease (Mpro) plays a crucial role in severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) replication and is highly conserved, rendering it one of the …

The main protease (Mpro, 3CLpro) of SARS-CoV-2 is an attractive target in coronaviruses
because of its crucial involvement in viral replication and transcription. Here, we report on …

The Coronavirus disease-19 (COVID-19) pandemic is still devastating the world causing
significant social, economic, and political chaos. Corresponding to the absence of globally …

Since the outbreak of COVID-19, the pandemic caused by SARS-CoV-2 infection is still
spreading at an alarming rate and has caused huge loss of life and economic damage …

The 21st century has witnessed three outbreaks of coronavirus (CoVs) infections caused by
severe acute respiratory syndrome (SARS)‐CoV, Middle East respiratory syndrome (MERS) …