Large-scale mapping studies have identified 236 independent genetic variants associated
with an increased risk of multiple sclerosis. However, none of these variants are found …

Genome-wide association studies have revolutionised the genetic analysis of multiple
sclerosis. Through international collaborative efforts involving tens of thousands of cases …

Multiple sclerosis (MS) is probably aetiologically heterogeneous. Systematic genetic
epidemiological and molecular genetic studies have provided important insights. Both …

Background Prediction of susceptibility to multiple sclerosis (MS) might have important
clinical applications, either as part of a diagnostic algorithm or as a means to identify high …

Clinical neurologists and scientists who study multiple sclerosis face open questions
regarding the integration of epidemiological data with genome-wide association studies and …

Multiple sclerosis (MS) is characterized by chronic inflammation and demyelination in the
central nervous system (CNS). Although the etiology of MS is unknown, both genetic and …

The increased recurrence risk within families indicates a role for genetic factors in the
etiology of multiple sclerosis. Genes may influence susceptibility to the development of …

Extensive epidemiologic data in the form of familial disease aggregation and differential
disease incidence across ancestral groups suggested that genetic variation is an important …

Genetic susceptibility to multiple sclerosis is implicated on the basis of classical family
studies and phenotype analyses. The only reproducible legacy from the candidate gene …

The uneven distribution of multiple sclerosis (MS) across populations can be attributed to
differences in genes and the environment and their interaction. Prevalence and incidence …