The prevalence of cardiovascular and metabolic disease coupled with kidney dysfunction is
increasing worldwide. This triad of disorders is associated with considerable morbidity and …

Nitrix oxide (NO) is a labile radical gas that is widely acclaimed as one of the most important
molecules in biology. Through covalent modifications of target proteins and redox reactions …

Cardiovascular disorders including hypertension and associated renal disease are major
health problems affecting more than 1.5 billion people worldwide. Apart from nonmodifiable …

The overall production of nitric oxide (NO) is decreased in chronic kidney disease (CKD)
which contributes to cardiovascular events and further progression of kidney damage. There …

Endothelial nitric oxide synthase (eNOS) serves a number of functions in the vasculature. In
response to stimuli such as shear stress or acetylcholine, eNOS catalyses the production of …

Cellular injury or organ dysfunction from oxidative stress occurs when reactive oxygen
species (ROS) accumulate in excess of the host defense mechanisms. The deleterious effect …

Nitric oxide (NO) is a gaseous free radical that serves cell signaling, cellular energetics, host
defense, and inflammatory functions in virtually all cells. In the kidney and vasculature, NO …

Inorganic nitrate (NO3−), nitrite (NO2−) and NO are nitrogenous species with a diverse and
interconnected chemical biology. The formation of NO from nitrate and nitrite via a reductive …

Nitric oxide (NO) plays an important regulatory/modulatory role in a variety of inflammatory
conditions. NO is a small, short-lived molecule that is released from a variety of cells in …

Nitric oxide (NO) is an important molecular mediator of numerous physiological processes in
virtually every organ. In the kidney, NO plays prominent roles in the homeostatic regulation …