Several arguments suggest that most hepatocellular carcinomas (HCCs) occurring in human
cirrhotic livers arise from large hepatocellular nodules or macronodules. Except for nodules …

The role of the large regenerative nodule (RN) in hepatocarcinogenesis is not clear,
although the incidence of hepatocellular carcinoma (HCC) is high in cirrhotic liver. This …

Most hepatocellular carcinomas (HCC) arise from malignant transformation of regenerative
cirrhotic nodules. Because HCC has a very poor prognosis, detection of these premalignant …

Data from experimental hepatocarcinogenesis and recent studies in humans have
suggested that the emergence of hepatocellular carcinoma (HCC) is a stepwise process …

Background/Aims: The natural outcome of ultrasound-detected macronodules in cirrhosis is
still poorly understood. In this study we assessed the incidence and predictors of malignant …

Recently, a growing literature has supported the concept that large nodules usually found in
cirrhotic livers represent premalignant lesions in chronic liver disease. Using advanced …

Methods Macroregenerative nodule classification was based on recently proposed
histological criteria. Extranodular liver cell dysplasia was also evaluated. The follow-up …

BACKGROUND Dysplastic nodules (DNs) recently have been identified as preneoplastic
lesions of hepatocellular carcinoma (HCC). To test an alternative hypothesis regarding DN …

C found to contain microscopic foci of HCC, further supporting the background nodule as a
premalignant lesion. 1 rucial to the understanding of how carcinoma arises in any organ and …

The number of dysplastic nodules detected clinically has increased since patients with
hepatitis virus-associated cirrhosis, who are at increased risk for hepatocellular carcinoma …