The gut-renal connection in IgA nephropathy

R Coppo - Seminars in nephrology, 2018 - Elsevier
The connection between a dysregulated gut-associated lymphoid tissue and IgA
nephropathy (IgAN) was supposed decades ago after the observation of increased …

The gut–kidney axis in IgA nephropathy: role of microbiota and diet on genetic predisposition

R Coppo - Pediatric nephrology, 2018 - Springer
Recent data suggest that gut-associated lymphoid tissue (GALT) plays a major role in the
development of immunoglobulin A (IgA) nephropathy (IgAN). A genome-wide association …

The mucosa–kidney axis in IgA nephropathy

J Floege, J Feehally - Nature Reviews Nephrology, 2016 - nature.com
Abstract Links between IgA nephropathy (IgAN) and the mucosa have been recognized
since the 1970s. In particular, the observation of visible haematuria induced by respiratory …

[HTML][HTML] Gluten exacerbates IgA nephropathy in humanized mice through gliadin–CD89 interaction

C Papista, S Lechner, SB Mkaddem, MB LeStang… - Kidney international, 2015 - Elsevier
IgA1 complexes containing deglycosylated IgA1, IgG autoantibodies, and a soluble form of
the IgA receptor (sCD89), are hallmarks of IgA nephropathy (IgAN). Food antigens, notably …

The intestine–renal connection in IgA nephropathy

R Coppo - Nephrology Dialysis Transplantation, 2015 - academic.oup.com
It is commonly stated that mucosal immunity plays a role in the pathogenesis of IgA
nephropathy (IgAN); however, the search for specific eliciting factors has been largely …

Role of IgA receptors in the pathogenesis of IgA nephropathy

SM Lechner, C Papista, JM Chemouny, L Berthelot… - Journal of …, 2016 - Springer
Immunoglobulin A nephropathy (IgAN) or Berger's disease is the most common form of
primary glomerulonephritis in the world and one of the first causes of end-stage renal failure …

Treatment of IgA nephropathy: Recent advances and prospects

R Coppo - Nephrologie & therapeutique, 2018 - Elsevier
IgA nephropathy, identified 50 years ago in France, is the most frequent glomerular disease
worldwide. The course is variable, but in most of the cases there is a relentless decline in …

New treatment for IgA nephropathy: enteric budesonide targeted to the ileocecal region ameliorates proteinuria

HK Smerud, P Bárány, K Lindström… - Nephrology Dialysis …, 2011 - academic.oup.com
Background. Systemic corticosteroid treatment has been shown to exert some protection
against renal deterioration in IgA nephropathy (IgAN) but is not commonly recommended for …

Why target the gut to treat IgA nephropathy?

J Barratt, BH Rovin, D Cattran, J Floege… - Kidney International …, 2020 - kireports.org
It is more than 50 years since the first description of IgA nephropathy (IgAN) by the Parisian
pathologist, Jean Berger. 1 Over this time, IgAN became recognized as the most common …

Cellular Signaling and Production of Galactose‐Deficient IgA1 in IgA Nephropathy, an Autoimmune Disease

C Reily, H Ueda, ZQ Huang, J Mestecky… - Journal of …, 2014 - Wiley Online Library
Immunoglobulin A (IgA) nephropathy (IgAN), the leading cause of primary
glomerulonephritis, is characterized by IgA1‐containing immunodeposits in the glomeruli …