[HTML][HTML] Glycated ACE2 receptor in diabetes: open door for SARS-COV-2 entry in cardiomyocyte

N D'onofrio, L Scisciola, C Sardu, MC Trotta… - Cardiovascular …, 2021 - Springer
Rationale About 50% of hospitalized coronavirus disease 2019 (COVID-19) patients with
diabetes mellitus (DM) developed myocardial damage. The mechanisms of direct SARS …

[HTML][HTML] Expression of the SARS-CoV-2 receptorACE2 in human heart is associated with uncontrolled diabetes, obesity, and activation of the renin angiotensin system

M Herman-Edelstein, T Guetta, A Barnea… - Cardiovascular …, 2021 - Springer
Background Diabetic and obese patients are at higher risk of severe disease and cardiac
injury in corona virus 2 (SARS-CoV-2) infections. Cellular entry of SARS-CoV-2 is mainly via …

Cell type-specific expression of the putative SARS-CoV-2 receptor ACE2 in human hearts

L Nicin, WT Abplanalp, H Mellentin, B Kattih… - European heart …, 2020 - academic.oup.com
The coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infections imposes a
major threat for the world's healthcare systems and is leading to thousands of deaths …

SARS-CoV-2 receptor ACE2 expression in the human heart: cause of a post-pandemic wave of heart failure?

T Thum - European Heart Journal, 2020 - academic.oup.com
The current ongoing pandemic COVID-19 (coronavirus disease outbreak at the end of 2019)
is based on a positive-sense single-stranded RNA virus associated with a nucleoprotein …

ACE2 (Angiotensin-Converting Enzyme 2) and TMPRSS2 (Transmembrane Serine Protease 2) expression and localization of SARS-CoV-2 infection in the human …

A Sakamoto, R Kawakami, K Kawai… - … and Vascular Biology, 2021 - Am Heart Assoc
At least 20% of patients hospitalized with corona-virus disease 2019 (COVID-19) have
evidence of cardiac injury and its presence increases mortality. 1 ACE 2 (angiotensin …

[HTML][HTML] Type-2 diabetes as a risk factor for severe COVID-19 infection

M Norouzi, S Norouzi, A Ruggiero, MS Khan, S Myers… - Microorganisms, 2021 - mdpi.com
The current outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2), termed coronavirus disease 2019 (COVID-19), has generated a notable challenge …

[HTML][HTML] Expression Profile of SARS-CoV-2 Host Receptors in Human Pancreatic Islets Revealed Upregulation of ACE2 in Diabetic Donors

J Taneera, W El-Huneidi, M Hamad, AK Mohammed… - Biology, 2020 - mdpi.com
Cellular entry of SARS-CoV-2 is thought to occur through the binding of viral spike S1
protein to ACE2. The entry process involves priming of the S protein by TMPRSS2 and …

[HTML][HTML] SARS-CoV-2 receptor ACE2-dependent implications on the cardiovascular system: From basic science to clinical implications

S Gross, C Jahn, S Cushman, C Baer… - Journal of molecular and …, 2020 - Elsevier
The current COVID-19 pandemic started several months ago and is still exponentially
growing in most parts of the world–this is the most recent and alarming update. COVID-19 …

[HTML][HTML] Viral infiltration of pancreatic islets in patients with COVID-19

C Steenblock, S Richter, I Berger, M Barovic… - Nature …, 2021 - nature.com
Metabolic diseases are associated with an increased risk of severe COVID-19 and
conversely, new-onset hyperglycemia and complications of preexisting diabetes have been …

Myocyte-Specific Upregulation of ACE2 in Cardiovascular Disease: Implications for SARS-CoV-2–Mediated Myocarditis

NR Tucker, M Chaffin, KC Bedi Jr, I Papangeli… - Circulation, 2020 - Am Heart Assoc
In contrast to a recent report, 4 analyses of bulk RNA-Seq data show no significant
alterations in ACE2 expression in the context of dilated or hypertrophic cardiomyopathy …