Currently, over 300 million people worldwide have depression, and the socioeconomic
burden of this debilitating disorder is anticipated to increase markedly over the coming …

Major depression disorder (MDD) is a debilitating mental illness with significant morbidity
and mortality. Despite the growing number of studies that have emerged, the precise …

Depression is among the most prevalent forms of psychiatric disorders and a leading cause
for morbidity and mortality. Since the serendipitous discovery of the first antidepressants the …

Major depression is a leading contributor to the global burden of disease. This situation is
mainly related to the chronicity and/or recurrence of the disorder, and to poor response to …

Animal models of depression are certainly needed but the question in the title has been
raised owing to the controversies in the interpretation of the readout in a number of tests, to …

Animal models of human disease have proven of considerable value in elucidating basic
pathophysiological mechanisms and in developing novel treatments. However, modelling …

Much of the current understanding about the pathogenesis of altered mood, impaired
concentration and neurovegetative symptoms in major depression has come from animal …

Depressive disorder is one of the most widespread forms of psychiatric pathology,
worldwide. According to a report by the World Health Organization, the number of people …

Depression is one of the leading causes of disability and a significant health-concern
worldwide. Much of our current understanding on the pathogenesis of depression and the …

In this article, we discuss what animal models of depression should be attempting to 'model'.
One must first determine if the goal is to model the regulatory mechanisms by which …