Initial expectations for genome-wide association studies were high, as such studies
promised to rapidly transform personalized medicine with individualized disease risk …

Genome-wide association studies have shown unequivocally that common complex
disorders have a polygenic genetic architecture and have enabled researchers to identify …

A problem at the interface of genomic medicine and medical screening is that genetic
associations of etiological significance are often interpreted as having predictive …

A new study highlights the biases and inaccuracies of polygenic risk scores (PRS) when
predicting disease risk in individuals from populations other than those used in their …

Polygenic inheritance is a non-Mendelian form of inheritance in which the risk of a trait,
disorder, or disease results from the combined contribution of variants from multiple genes …

Most common diseases are caused by multiple genetic and environmental factors. In the last
2 years, genome-wide association studies (GWAS) have identified polymorphisms that are …

Editorial summary Genome-wide association studies have made strides in identifying
common variation associated with disease. The modest effect sizes preclude risk prediction …

The brisk discovery of novel inherited disease markers by genome-wide association (GWA)
studies has raised expectations for predicting disease risk by analysing multiple common …

Abstract Knowledge of genetics and its implications for human health is rapidly evolving in
accordance with recent events, such as discoveries of large numbers of disease …

Genome‐wide variation data with millions of genetic markers have become commonplace.
However, the potential for interpretation and application of these data for clinical assessment …