Colchicine (COL), a widely used natural drug, has potent anti-inflammatory effects; however,
as a narrow therapeutic index drug, its clinical application is limited by its serious …

Historically known as “the disease of kings,” gout is one of the oldest known types of arthritis,
affecting more than 40 million people worldwide, prevalent in patients between 30 and 50 …

Gout is a common inflammatory disease that is characterized by the deposition of serum
urate crystals in the synovial fluids and joints. In spite of high efficiency of colchicine (COL) in …

Various therapeutic effects have been found for alkaloids. However, severe side effects can
limit the clinical applications of these bioactive compounds. Colchicine alkaloid as an anti …

Introduction Colchicine is used for the treatment of gout, pseudo-gout, familial
Mediterranean fever, and many other illnesses. Its oral administration is associated with …

Gout is one of the most prevalent rheumatic diseases, globally. Colchicine (COL) is the first-
line drug used for the treatment of acute gout. However, the oral administration of COL is …

Colchicine, an alkaloid found in extracts of the plants Colchicum autumnale and Gloriosa
superb, is effective in the treatment of acute gout and dermatological conditions like leuko …

Colchicine (CL) is the most effective treatment of acute gout, however, it is associated with
side effects in 80% of the patients at therapeutic doses, in addition, it's a water-soluble …

Colchicine is the first-line option for both the treatment and prophylaxis of gout flares.
However, due to potentially severe side effects, the clinical use of colchicine is limited. A well …

Currently, high protein and fat food in daily diet often causes the prevalence of gout, which is
common treated with colchicine as specific medicine. Transdermal delivery with …