Neurodegeneration of the central and enteric nervous systems is a common feature of aging
and aging-related diseases, and is accelerated in individuals with metabolic dysfunction …

Sirtuins are highly conserved NAD+-dependent enzymes that have beneficial effects against
age-related diseases. Aging is the major unifying risk factor for all neurodegenerative …

Brain aging is characterized by progressive loss of neurophysiological functions that is often
accompanied by age-associated neurodegeneration. Calorie restriction has been linked to …

Silent i nformation r egulator 2 prote ins (sirt uin s or SIRTs) are a group of deacetylases (or
deacylases) whose activities are dependent on and regulated by nicotinamide adenine …

Sirtuins are an evolutionarily conserved family of regulatory proteins that function in an
NAD+-dependent manner. The mammalian family of sirtuins is composed of seven histone …

Silent information regulator two proteins (sirtuins or SIRTs) are a group of histone
deacetylases whose activities are dependent on and regulated by nicotinamide adenine …

Enteric neuron degeneration has been observed during aging, and in individuals with
metabolic dysfunction including obesity and diabetes. Honokiol, a naturally occurring …

Sirtuins are a conserved family of deacetylases whose activities are dependent on
nicotinamide adenine dinucleotide (NAD+). Sirtuins act in different cellular compartments …

Sirtuins (SIRTs) are a family of regulatory proteins of genetic information with a high degree
of conservation among species. The SIRTs are heavily involved in several physiological …

Obesity is a chronic disease characterized by persistent low-grade inflammation with
alterations in gut motility. Motor abnormalities suggest that obesity has effects on the enteric …