Cryo-electron microscopy structures of the N501Y SARS-CoV-2 spike protein in complex with ACE2 and 2 potent neutralizing antibodies

X Zhu, D Mannar, SS Srivastava, AM Berezuk… - PLoS …, 2021 - journals.plos.org
The recently reported “UK variant”(B. 1.1. 7) of SARS-CoV-2 is thought to be more infectious
than previously circulating strains as a result of several changes, including the N501Y …

Effect of SARS-CoV-2 B. 1.1. 7 mutations on spike protein structure and function

TJ Yang, PY Yu, YC Chang, KH Liang… - Nature structural & …, 2021 - nature.com
Abstract The B. 1.1. 7 variant of SARS-CoV-2 first detected in the UK harbors amino-acid
substitutions and deletions in the spike protein that potentially enhance host angiotensin …

Structure and mutations of SARS-CoV-2 spike protein: a focused overview

R Mehra, KP Kepp - ACS Infectious Diseases, 2021 - ACS Publications
The spike protein (S-protein) of SARS-CoV-2, the protein that enables the virus to infect
human cells, is the basis for many vaccines and a hotspot of concerning virus evolution …

SARS-CoV-2 Omicron variant: Antibody evasion and cryo-EM structure of spike protein–ACE2 complex

D Mannar, JW Saville, X Zhu, SS Srivastava… - Science, 2022 - science.org
The newly reported Omicron variant is poised to replace Delta as the most prevalent severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant across the world. Cryo …

Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient

D Zhou, HME Duyvesteyn, CP Chen… - Nature structural & …, 2020 - nature.com
The COVID-19 pandemic has had an unprecedented health and economic impact and there
are currently no approved therapies. We have isolated an antibody, EY6A, from an …

Structural basis for potent neutralization of SARS-CoV-2 and role of antibody affinity maturation

NK Hurlburt, E Seydoux, YH Wan, VV Edara… - Nature …, 2020 - nature.com
SARS-CoV-2 is a betacoronavirus virus responsible for the COVID-19 pandemic. Here, we
determine the X-ray crystal structure of a potent neutralizing monoclonal antibody, CV30 …

Antibody neutralization of SARS-CoV-2 through ACE2 receptor mimicry

J Ge, R Wang, B Ju, Q Zhang, J Sun, P Chen… - Nature …, 2021 - nature.com
Understanding the mechanism for antibody neutralization of SARS-CoV-2 is critical for the
development of effective therapeutics and vaccines. We recently isolated a large number of …

Conformational dynamics of the Beta and Kappa SARS-CoV-2 spike proteins and their complexes with ACE2 receptor revealed by cryo-EM

Y Wang, C Xu, Y Wang, Q Hong, C Zhang, Z Li… - Nature …, 2021 - nature.com
The emergence of SARS-CoV-2 Kappa and Beta variants with enhanced transmissibility
and resistance to neutralizing antibodies has created new challenges for the control of the …

Evolution of the SARS-CoV-2 spike protein in the human host

AG Wrobel, DJ Benton, C Roustan, A Borg… - Nature …, 2022 - nature.com
Recently emerged variants of SARS-CoV-2 contain in their surface spike glycoproteins
multiple substitutions associated with increased transmission and resistance to neutralising …

[HTML][HTML] Structural analysis of receptor binding domain mutations in SARS-CoV-2 variants of concern that modulate ACE2 and antibody binding

D Mannar, JW Saville, X Zhu, SS Srivastava… - Cell Reports, 2021 - cell.com
The recently emerged severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) Beta
(B. 1.351) and Gamma (P. 1) variants of concern (VoCs) include a key mutation (N501Y) …