Interleukin-11 is a pleotropic cytokine produced by lung stromal cells in response to
respiratory viruses, cytokines, and histamine. To further define its potential effector functions …

Interleukin (IL)-9, a pleiotropic cytokine produced by the Th2 subset of T lymphocytes has
been proposed as product of a candidate gene responsible for asthma. Its wide range of …

Noninflammatory structural alterations, variously referred to as airway remodeling, are well
documented in the asthmatic airway. However, the pathogenesis of these alterations, the …

To address the complex chronic effector properties of interleukin (IL)-10, we generated
transgenic mice in which IL-10 was overexpressed in the lung. In these mice, IL-10 inhibited …

Interleukin (IL)-13 is a pleiotropic cytokine produced in large quantities by activated CD4+
Th2 lymphocytes. To define further its potential in vivo effector functions, the Clara cell 10 …

We have generated transgenic mice that constitutively express murine interleukin (IL)-5 in
the lung epithelium. Airway expression of this cytokine resulted in a dramatic accumulation …

To investigate the contribution of interleukin-4 (IL-4) to airway inflammation in vivo and to
explore directly its relationship to airway reactivity, we created transgenic mice in which the …

We produced transgenic mice which overexpress human IL-6 in the airway epithelial cells.
Transgenic mice develop a mononuclear cell infiltrate adjacent to large and mid-sized …

Interleukin (IL)-13, a cytokine released by T lymphocytes during immediate hypersensitivity
responses, is a central mediator of asthma. Because IL-13 induces phenotypic features of …

The evolution of our understanding of IL-11 mirrors, in many ways, the problems that are
faced by investigators in the post-genome era and the types of techniques that might need to …