The effect of single-cell knockout of Fragile X Messenger Ribonucleoprotein on synaptic structural plasticity

M Gredell, J Lu, Y Zuo - Frontiers in Synaptic Neuroscience, 2023 - frontiersin.org
Fragile X Syndrome (FXS) is the best-known form of inherited intellectual disability caused
by the loss-of-function mutation in a single gene. The FMR1 gene mutation abolishes the …

Fragile X mental retardation protein induces synapse loss through acute postsynaptic translational regulation

BE Pfeiffer, KM Huber - Journal of neuroscience, 2007 - Soc Neuroscience
Fragile X syndrome, as well as other forms of mental retardation and autism, is associated
with altered dendritic spine number and structure. Fragile X syndrome is caused by loss-of …

Quantitative proteomic analysis of primary neurons reveals diverse changes in synaptic protein content in fmr1 knockout mice

L Liao, SK Park, T Xu, P Vanderklish… - Proceedings of the …, 2008 - National Acad Sciences
Fragile X syndrome (FXS) is a common inherited form of mental retardation that is caused, in
the vast majority of cases, by the transcriptional silencing of a single gene, fmr1. The …

Altered cortical Cytoarchitecture in the Fmr1 knockout mouse

FHF Lee, TKY Lai, P Su, F Liu - Molecular brain, 2019 - Springer
Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by silencing of the
FMR1 gene and subsequent loss of its protein product, fragile X retardation protein (FMRP) …

Fmr1 deficiency promotes age-dependent alterations in the cortical synaptic proteome

B Tang, T Wang, H Wan, L Han, X Qin… - Proceedings of the …, 2015 - National Acad Sciences
Fragile X syndrome (FXS) is an X-linked neurodevelopmental disorder characterized by
severe intellectual disability and other symptoms including autism. Although caused by the …

Subregion-specific dendritic spine abnormalities in the hippocampus of Fmr1 KO mice

J Levenga, FMS de Vrij, RAM Buijsen, T Li… - Neurobiology of learning …, 2011 - Elsevier
Fragile X syndrome (FXS) is the most common inherited form of mental retardation and is
caused by the lack of fragile X mental retardation protein (FMRP). In the brain, spine …

Reversal of activity‐mediated spine dynamics and learning impairment in a mouse model of F ragile X syndrome

B Boda, P Mendez, B Boury‐Jamot… - European Journal of …, 2014 - Wiley Online Library
Fragile X syndrome (FXS) is characterized by intellectual disability and autistic traits, and
results from the silencing of the FMR 1 gene coding for a protein implicated in the regulation …

Hippocampal pyramidal cells in adult Fmr1 knockout mice exhibit an immature-appearing profile of dendritic spines

AW Grossman, NM Elisseou, BC McKinney… - Brain research, 2006 - Elsevier
Fragile X syndrome (FXS) is a common form of mental retardation caused by the absence of
functional fragile X mental retardation protein (FMRP). FXS is associated with elevated …

Proteomics, ultrastructure, and physiology of hippocampal synapses in a fragile X syndrome mouse model reveal presynaptic phenotype

P Klemmer, RM Meredith, CD Holmgren… - Journal of Biological …, 2011 - ASBMB
Fragile X syndrome (FXS), the most common form of hereditary mental retardation, is caused
by a loss-of-function mutation of the Fmr1 gene, which encodes fragile X mental retardation …

[HTML][HTML] Sunrise at the synapse: the FMRP mRNP shaping the synaptic interface

LN Antar, GJ Bassell - Neuron, 2003 - cell.com
Recent studies provide new insight into the mechanistic function of Fragile X Mental
Retardation Protein (FMRP), paving the way to understanding the biological basis of Fragile …