Abstract Cyclin-dependent kinase 4 (CDK4) and CDK6 are critical mediators of cellular
transition into S phase and are important for the initiation, growth and survival of many …

Cell cycle dysregulation is a hallmark of all cancers, resulting in uncontrolled proliferation.
Cyclin dependent kinases (CDKs), a family of proteins that are involved in the regulation of …

BACKGROUND Cyclins and cyclin-dependent kinases (CDKs) drive cell division. Of
particular importance to the cancer field are D-cyclins, which activate CDK4 and CDK6. In …

The cyclin D-CDK4/6 complexes play a pivotal role in controlling the cell cycle. Deregulation
in cyclin D-CDK4/6 pathway has been described in many types of cancer and it invariably …

Pharmacologic inhibitors of cyclin-dependent kinases 4 and 6 (CDK4/6) have recently
entered the therapeutic armamentarium of clinical oncologists, and show promising activity …

Breast Cancer (BC) is the second most common type of cancer worldwide and displays the
highest cancer-related mortality among women worldwide. Targeted therapies have …

Abstract Cyclin-dependent kinases 4 and 6 (CDK4/6) have emerged as important
therapeutic targets. Pharmacologic inhibitors of these kinases function to inhibit cell-cycle …

Inhibiting the cell-cycle kinases CDK4 and CDK6 results in significant therapeutic effect in
patients with advanced hormone-positive breast cancer. The efficacy of this strategy is …

The cyclin D/cyclin-dependent kinases 4 and 6 (CDK4/6)–retinoblastoma protein (RB)
pathway plays a key role in the proliferation of both normal breast epithelium and breast …

Control of the cell cycle through selective pharmacological inhibition of CDK4/6 has proven
beneficial in the treatment of breast cancer. Extending this level of control to additional cell …