Countless times each day, the acute inflammatory response protects us from invading
microbes, injuries, and insults from within, as in surgery-induced tissue injury. These …

Inflammation is associated with the development of diseases characterized by altered
nutrient metabolism. Although an acute inflammatory response is host-protective and …

Today, persistent and uncontrolled inflammation is appreciated to play a pivotal role in many
diseases, such as cardiovascular diseases, neurodegenerative diseases, metabolic …

Practitioners of ancient societies from the time of Hippocrates and earlier recognized and
treated the signs of inflammation, heat, redness, swelling, and pain with agents that block or …

Acute inflammation is a host-protective response that is mounted in response to tissue injury
and infection. Initiated and perpetuated by exogenous and endogenous mediators, acute …

Resolvins, belonging to the group of specialized proresolving mediators (SPMs), are
metabolic products of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) and are …

Using a systems approach to profile self‐limited inflammatory exudates, we identified three
novel families of lipid‐derived mediators, coined the resolvins, protectins and most recently …

Mounting of the acute inflammatory response is crucial for host defense and pivotal to the
development of chronic inflammation, fibrosis, or abscess formation versus the protective …

While protective, the acute inflammatory response when uncontrolled can lead to further
tissue damage and chronic inflammation that is now widely recognized to play important …

The critical role of inflammatory processes in health and disease has long been recognized,
1 yet the detailed molecular mechanisms and biological events that regulate the progression …