Emerging evidence suggests that arginase contributes to endothelial dysfunction in
diabetes. Intracellular signaling pathways, which interplay between arginase and eNOS …

Diabetes mellitus is a major risk factor for the development of cardiovascular disease due to
increased vascular inflammatory and oxidative stress favouring atherogenesis. Endothelial …

Background and Purpose Emerging evidence suggests a selective up‐regulation of
arginase I in diabetes causing coronary artery disease; however, the mechanisms behind …

Diabetes-induced vascular endothelial dysfunction has been reported to involve
hyperglycemia-induced increases in arginase activity. However, upstream mediators of this …

L-Arginine (L-arg) is not only the substrate for nitric oxide synthase (NOS) to produce NO,
but also for arginase, which catalyzes conversion L-arg to ornithine and urea. In diabetes …

Endothelial dysfunction is a characteristic feature in diabetes that contributes to the
development of vascular disease. Recently, arginase has been implicated in triggering …

Aims Elevation of arginase activity has been linked to vascular dysfunction in diabetes and
hypertension by a mechanism involving decreased nitric oxide (NO) bioavailability due to L …

Background There is great interest to understand causal pathophysiological correlation
between obesity and diabetes mellitus (DM). Vascular endothelial dysfunction is crucially …

Arginase may play a major role in the regulation of vascular function in various
cardiovascular disorders by impairing nitric oxide (NO) production. In the current study, we …

Endothelial dysfunction represents an early change in the vascular wall in areas prone to
atherosclerotic plaque formation and is present in association with several risk factors for …