Inflammatory demyelination and axonal injury of the optic nerve are hallmarks of optic
neuritis (ON), which often occurs in multiple sclerosis and is a major cause of visual …

Axonal destruction and neuronal loss occur early during multiple sclerosis, an autoimmune
inflammatory CNS disease that frequently manifests with acute optic neuritis. Available …

Neuro-axonal injury in the central nervous system (CNS) is one of the major pathological
hallmarks of experimental autoimmune encephalomyelitis (EAE), an experimental model of …

Optic neuritis is a common clinical manifestation of the chronic inflammatory CNS disease
multiple sclerosis that can result in persistent visual impairment caused by degeneration of …

Background Neuromyelitis optica spectrum disorder (NMOSD), an autoimmune
astrocytopathic disease associated with the anti-aquaporin-4 (AQP4) antibody, is …

Aims Matrine (MAT), a quinolizidine alkaloid derived from the herb Radix Sophorae
flavescens, has been recently found to be beneficial in experimental autoimmune …

Abstract Inflammation, demyelination, oligodendrocyte (OLG) death, and axonal
degeneration are primary characteristics of multiple sclerosis (MS) and its animal model …

Stressed oligodendrocytes (OLGs) activate microglia to produce an inflammatory response,
and the impairment of mitochondria further aggravates OLG damage, which is the earliest …

Experimental autoimmune encephalomyelitis (EAE) is a classical experimental model of
multiple sclerosis (MS), an autoimmune disease of the central nervous system (CNS) …

Optic neuritis is an acute inflammatory demyelinating disorder of the optic nerve (ON) and is
an initial symptom of multiple sclerosis (MS). Optic neuritis is characterized by ON …