Live probiotic bacteria administered in a pathomimetic Leaky Gut Chip ameliorate impaired epithelial barrier and mucosal inflammation
Here, we report a pathomimetic Leaky Gut Chip that recapitulates increased epithelial
permeability and intestinal inflammation to assess probiotic intervention as live …
permeability and intestinal inflammation to assess probiotic intervention as live …
Contributions of the microbiome to intestinal inflammation in a gut-on-a-chip
MS Jeon, YY Choi, SJ Mo, JH Ha, YS Lee, HU Lee… - Nano …, 2022 - Springer
The intestinal microbiome affects a number of biological functions of the organism. Although
the animal model is a powerful tool to study the relationship between the host and microbe …
the animal model is a powerful tool to study the relationship between the host and microbe …
Gut-on-chip: Recreating human intestine in vitro
The human gut is important for food digestion and absorption, as well as a venue for a large
number of microorganisms that coexist with the host. Although numerous in vitro models …
number of microorganisms that coexist with the host. Although numerous in vitro models …
[HTML][HTML] Gut-on-a-chip models for dissecting the gut microbiology and physiology
Microfluidic technologies have been extensively investigated in recent years for developing
organ-on-a-chip-devices as robust in vitro models aiming to recapitulate organ 3D …
organ-on-a-chip-devices as robust in vitro models aiming to recapitulate organ 3D …
Immunoresponsive microbiota-gut-on-chip reproduces barrier dysfunction, stromal reshaping and probiotics translocation under inflammation
V De Gregorio, C Sgambato, F Urciuolo, R Vecchione… - Biomaterials, 2022 - Elsevier
Here, we propose an immune-responsive human Microbiota-Intestine axis on-chip as a
platform able to reproduce the architecture and vertical topography of the microbiota with a …
platform able to reproduce the architecture and vertical topography of the microbiota with a …
Intestinal barrier dysfunction orchestrates the onset of inflammatory host–microbiome cross-talk in a human gut inflammation-on-a-chip
The initiation of intestinal inflammation involves complex intercellular cross-talk of
inflammatory cells, including the epithelial and immune cells, and the gut microbiome. This …
inflammatory cells, including the epithelial and immune cells, and the gut microbiome. This …
Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip
HJ Kim, H Li, JJ Collins… - Proceedings of the …, 2016 - National Acad Sciences
A human gut-on-a-chip microdevice was used to coculture multiple commensal microbes in
contact with living human intestinal epithelial cells for more than a week in vitro and to …
contact with living human intestinal epithelial cells for more than a week in vitro and to …
Mucosal immunity–mediated modulation of the gut microbiome by oral delivery of probiotics into Peyer's patches
Methods capable of maintaining gut microbiota homeostasis to prevent bacterial
translocation and infection under external threats are critical for multiple facets of human …
translocation and infection under external threats are critical for multiple facets of human …
Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow
Development of an in vitro living cell-based model of the intestine that mimics the
mechanical, structural, absorptive, transport and pathophysiological properties of the human …
mechanical, structural, absorptive, transport and pathophysiological properties of the human …
Farewell to animal testing: innovations on human intestinal microphysiological systems
TH Kang, HJ Kim - Micromachines, 2016 - mdpi.com
The human intestine is a dynamic organ where the complex host-microbe interactions that
orchestrate intestinal homeostasis occur. Major contributing factors associated with intestinal …
orchestrate intestinal homeostasis occur. Major contributing factors associated with intestinal …